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Shortness of breath during covid-19
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Gridhot.ID – Covid-19 virus infection can infect anyone with different symptoms.
However, recently appeared research question Men more likely to experience severe symptoms moment infected corona virus.
Apparently it is known that Men are the group that is more likely to suffer from Covid-19 cases with severe symptoms and more at risk of death.
The researchers studied the relationship between these.
They found that the metabolic pathway was highly correlated with the immune response of male patients with Covid-19.
Reported by Intisari-Online from Science Signaling, which published new research, revealed that male Covid-19 patients were more likely to have elevated kynurenic acid levels, compared to female Covid-19 patients.
Kynurenic acid is a product of amino acid metabolism.
High levels of kynurenic acid are usually associated with several diseases, such as schizophrenia and HIV-related illnesses.
Male patients with positive COVID-19 cases with severe symptoms were more likely to have a high kynurenic acid to kynurenine ratio.
Kynurenine, a by-product of the amino acid L-tryptophan, is used to make the nutrient niacin.
“We know that men are at higher risk than women of contracting severe COVID-19 and that sex differences in immune responses provide a compelling explanation for this phenomenon,” said Caroline Johnson, assistant professor of epidemiology at the Yale School of Public Health and senior author. this study.
“We also know that the immune response is regulated in part by metabolites, and these new findings offer a key window into the underlying mechanisms for how this COVID-19 disease affects female and male patients differently.”
Johnson worked closely with Akiko Iwasaki, Professor of Immunobiology and Molecular Biology, Waldemar Von Zedtwitz, who previously led the research team to identify significant differences in the way women’s and men’s immune systems respond to the coronavirus that causes Covid-19.
The Yale School of Public Health provided rapid response funding so that Johnson, postdoctoral fellow Yuping Cai, and their team could study blood samples taken from 22 female and 17 male patients at Yale New Haven Hospital after confirmed Covid-19 infection.
The samples were then compared with samples from 20 healthcare providers who were not infected with Covid-19.
The researchers positively identified 75 metabolites, which are molecular products of digestive processes and cellular metabolism.
Researchers then adjusted for the patient’s age, body mass index, gender, and other characteristics, so they determined there were 17 metabolites associated with Covid-19 infection.
Further analysis revealed a strong association between high levels of kynurenic acid and a high ratio of kynurenic acid to kynurenine in the male immune response and poorer outcomes of Covid-19 patients.
According to Johnscon, sex-specific pathway studies like these provide key clues to how the disease infects and makes people sick.
“We can use this knowledge to create more effective treatments for this terrible disease Covid-19 and similar diseases.”
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