We all want to get rid of excessFat, but body fat always seems stubborn. But this is only a superficial phenomenon. In fact, adipose tissue, like the organs of our body, is constantly metabolized and regenerated, and the life of fat cells is also limited. Eating the right food can “starve” dead fat cells.
Fatgrowth requires blood vessels to supply nutrients
On a microscopic level, adipose tissue is not only the white cellulite that we see with the naked eye, but also a huge number of capillaries that pass through it.
“Fat is like any other tissue: it needs a blood supply to stay alive.” Eat to Beat Disease author, president of the Angiogenesis Foundation and the former Harvard Medical School, Dr. Vintage times.
A normal person maintains a balance of fat in the body. “When fat grows in the body beyond its normal proportions, it results in excess fatty tissue, which requires more blood supply,” Li Weilin said.
The production of fat depends on the blood vessels.In particular, if the adipocytes continuously store lipids in the lipid droplets, their size will gradually expand and the adipocytes will be deprived of oxygen and this mild hypoxic state will allow the fat to release a series factors related to angiogenesis that induce the formation of new blood blood vessels, which supply oxygen and nutrients to the cells and allow the growth of adipose tissue[1]。
As fat builds up in the body, it is not only the bones and muscles that gain weight, but the heart as well. For every pound a person gains, about 5 miles of blood vessels are created to support the survival of these fat cells. Therefore, the heart has to pump blood farther and farther. Faced with increasingly difficult tasks, a range of cardiovascular health problems will follow, such as increased blood pressure, increased rates of heart disease, etc.[2]。
Excess fat not only affects the endocrine system, it also impairs organ function
And apparently inert fat, inactive, in fact, the endocrine is very strong.
There are two types of fat in our body, white fat and brown fat. Li Weilin said that for the human body, brown fat is like a “heater” in a room, while white adipose tissue is not only an energy storage tissue, but also an important endocrine organ.
White fat secretes many hormones, including leptin, adipsin, angiotensinogen, adiponectin, resistin, etc., and also produces steroid hormones. These hormones affect energy homeostasis, glucose and lipid metabolism, vascular homeostasis, immune responses and even fertility.When the mass of white fat changes significantly, almost anything that is secreted from it can be altered or even dysregulated[3]。
Additionally, when a person gains weight, fatty tissue becomes dysfunctional due to lack of oxygen and inflammation, which releases large amounts of free fatty acids and adipokines into the bloodstream. These substances travel with the blood to other organs such as the liver, heart and large arteries, where they eventually accumulate in these tissues and change their properties and impair their function.
Therefore, controlling the white fat in the body at a reasonable level is very important for maintaining the health of the human body.
Stops blood vessel growth, controls fat growth
Li Weilin made it clear in the interview that “laboratory studies have shown that prevent growth[in eccesso]of blood vessels can control the growth of fat. “He said this approach is the same as what is called” anti-angiogenesis, “which” has been used. It has been shown that cancer growth can be stopped by stopping cancer. rushing blood and starving cancer cells. (Recommended reading:Many people have cancer cells! Eating these foods often starves cancer cells）
Many animal experiments have shown that the use of anti-angiogenic substances to inhibit and prevent angiogenesis of fat cells can manage and treat high fat.dietobesity[4]。
The scientists treated the mice that had grown chubby after eating a high-calorie diet with an anti-angiogenic substance for 28 days. Throughout the entire process, the mice were still fed a high-calorie diet. But it was found that these otherwise obese mice lost about 30% of their body weight and lost an average of 15 grams each after receiving the anti-angiogenic substance, while the control group of mice did not receive the anti-angiogenic treatment. angiogenic and continued to gain weight.
Furthermore, mice treated with anti-angiogenic substances had reduced postprandial blood glucose levels and insulin secretion levels.[5]。
Scientists also used monkeys to conduct experiments: Obese rhesus monkeys spontaneously lost 7% to 15% of their body weight, 38% of body fat and 27% of abdominal fat after 28 days of treatment with anti-inflammatory drugs. -angiogenic. marked improvement in insulin resistance.
And scanned images of his body show that rhesus monkeys’ weight loss is primarily achieved by reducing fat tissue and there are no fluid loss issues or muscle wasting.[6]。
Eat these foods and starve your fat cells
Many obese people may be looking forward to the launch of related drugs, and Li Weilin said, “Anti-angiogenesis therapy for fat is still in the research phase of drug development.” And she also pointed out in her book that new therapies are needed at cost and availability. The problem is not necessarily within everyone’s reach. Furthermore, these drugs are designed to treat the disease, not to prevent the problem.
But it also provided another convenient and feasible solution that has proven effective in many experiments, namely eating “certain foods that contain substances that can inhibit angiogenesis.”
1. green tea
One of the foods that Li Weilin specifically mentioned isgreen tea。
During green tea processing, the tea leaves are heated to inactivate the enzymes. The shrinking and drying process of the leaves prevents leaf autolysis and oxidation of the components. The drying process of the tea leaves also contributes to the stabilization of the ingredients during storage.
Green tea is rich in a variety of catechins and, among these, epigallocatechin-3-gallate, called EGCG (epigallocatechin-3-gallate) is the most abundant and active catechin in green tea. , representing 50% to 80% of the catechin content[7]。
For example, a 250ml cup of green tea prepared with 2.5 grams of tea leaves contains 240-320 mg of catechins, of which 60-65% is EGCG[8]。EGCG can down-regulate angiogenesis-related molecular signals and induce apoptosis, thus having an anti-angiogenic effect[9]。
EGCG catechin is effective against angiogenesis. In clinical laboratory and human studies, catechins have been shown to reduce fat growth.
A recent systematic review and meta-analysis showed that in more than 20 green tea studies, people who drank green tea or supplements lost an average of 1.78 kg of body weight and an average of 0.65 kg /. m² of body mass index.[10]。
In a controlled study, postmenopausal women in the United States took green tea extract capsules (at doses of 400 or 800 mg EGCG and a small amount of other catechins) daily for 2 months, compared to a control group. with placebo, they took EGCG to significantly lower blood LDL cholesterol, glucose and insulin levels in these women[11]。
2. Tomato
Lycopene, which is rich in tomatoes, has anti-angiogenic effects, which is why it can effectively inhibit prostate cancer[12]. Lycopene at a concentration of 10 μM can significantly inhibit angiogenesis of endothelial cells of the human umbilical vein, reduce angiogenesis branch points by 55% and reduce vessel length by 40%[13]。
However, in order to achieve the protective effect of lycopene in tomato on the body, a healthy onedietmeeting.Because experiments have found that the protective effect of lycopene is lost if a high-calorie diet is used to induce obesity.[14]。
Lycopene can promote metabolism and reduce body fat. A study of lycopene intake and metabolic diseases in 374 middle-aged and older Dutchmen showed that higher lycopene intake was associated with a lower risk of metabolic disease. Compared to those who consumed less lycopene, those who ate more lycopene in their diet had a 45% lower risk of developing metabolic diseases, had lower waist circumference and visceral and subcutaneous fat mass, and serum triglyceride content was also low[15]。
3. coffee
Li Weilin also mentioned foods containing chlorogenic acid, such ascoffee。
Experiments have shown that chlorogenic acid can inhibit angiogenesis of human cells.When the concentration of chlorogenic acid is 25 μM and 50 μM, the rate of inhibition of chlorogenic acid on epidermal growth factor activity respectively reaches 10% and 18%.[16]。
In 150 overweight adults who drank coffee with 300 mg of chlorogenic acid daily for 12 weeks, visceral fat area, total abdominal fat area, body weight and waist circumference were significantly reduced compared to those who had drank coffee with a lower chlorogenic acid content[17]。
Additionally, Weilin Li recommends these foods: vegetables that contain sulforaphane, such as kale, broccoli and kale; vegetables that contain quercetin, such as red onions; and foods that contain beta-glucans, such as mushrooms; and There is wakame with omega-3 fatty acids. In human studies, these foods have been shown to reduce body fat and improve metabolism. The Mediterranean diet also has a positive defense against angiogenesis.
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Responsible editor: Li Qingfeng
