GridHEALTH.id – Treatment Diffuse large B-cell lymphoma (DLBCL) patients have to undergo for a long time. This is what it looks like Ari Lasso.
To note, treating DLBCL will most likely cause physical changes in the sufferer’s body.
The treatment can be very intense. Patients with diffuse large B-cell lymphoma (DLBCL) may be in and out of the hospital for at least several months.
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These changes may be difficult to cope with and can affect how the patient feels.
In addition, patients may also have to cope with feeling very tired and lethargic all the time, especially for some time after treatment.
Therefore, for patients with Diffuse large B-cell lymphoma (DLBCL), it is better to ask for support from family, family, and friends.
It’s even better to join a group or community of fellow sufferers of Diffuse large B-cell lymphoma (DLBCL).
It is also important for people with Diffuse large B-cell lymphoma (DLBCL), launched Cancer Research UK in the scientific article ‘Diffuse large B-cell lymphoma’, that the best person to talk to themselves about their outlook or prognosis is a doctor.
Regarding the patient’s survival depends on many factors.
So no one can tell how long the patient will live.
But rest assured if the patient is enthusiastic, consistently undergoes treatment, his condition will be able to recover.
DLBCL treatment goals
* cure lymphoma
* control lymphoma as long as possible
* control symptoms
* stop the spread of lymphoma to other parts of the body (such as cerebrospinal fluid)
stop lymphoma from coming back
It is important to remember that, because DLBCL develops rapidly, patients should seek treatment as soon as diagnosis is made.
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Remember, if there are no signs of lymphoma after treatment, this is called remission.
Because sometimes DLBCL can come back again. If this happens the patient will usually have more treatment.
Treatment of DLBCL depends on:
* where does lymphoma occur
* perceived symptoms
* general health of the patient
* how many chemicals are in the patient’s blood
* diagnostic results, ‘is the lymphoma likely to return after treatment?’
Chemotherapy and immunotherapy (chemoimmunotherapy)
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DLBCL treatment is usually with a number of different chemotherapy drugs; steroids and a targeted immunotherapy drug called rituximab (Mabthera). Komini is called chemoimmunotherapy.
But there are different combinations. One of the main combinations is R-CHOP.
These include the drugs rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone.
Patients will undergo this treatment therapy on certain days for 3 weeks. Each 3 week period is called a treatment cycle.
For earlier stage DLBCL, patients have 3 to 4 cycles.
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The treatment will be longer, 6 to 8 cycles, if the patient has more advanced disease, such as R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin and methotrexate), followed by R-IVAC (rituximab, ifosfamide, etoposide and cytarabine)
Patients may have a less intensive combination if they are older, or less fit and healthy.
It may exclude certain medications or have a lower dose of the drug to reduce side effects. For example, R-mini-CHOP.
Chemotherapy to stop the spread to the brain
Some types of lymphoma (including DLBCL) are more likely to spread to the brain and spinal cord (central nervous system).
If there is a high risk of the lymphoma spreading to the central nervous system, the doctor may want the patient to undergo treatment to prevent this.
The most common treatment is to inject the chemotherapy drug methotrexate into the fluid around the spinal cord.
Doctors may also recommend injecting high doses of methotrexate into a vein.
Treatment is usually if the patient’s lymphoma is in the breast, testes, adrenal glands, or kidneys.
To note, chemotherapy into the fluid that circulates around the brain and spinal cord is called intrathecal chemotherapy.
Radiotherapy
Patients may also receive radiotherapy, after chemotherapy to stop the lymphoma from returning, before stem cell or bone marrow transplants
Operation
Patients may have surgery to:
* remove lymph nodes for diagnosis and staging
relieve symptoms if the mass presses on the organ causing the blockage (obstruction)
* Stem cell or bone marrow transplant
Bone marrow is the spongy substance inside your bones. It contains stem cells. Stem cells develop into red blood cells, white blood cells and platelets.
* Stem cell transplantation allows patients to undergo high-dose chemotherapy. Patients may have a transplant using:
– your own stem cells (autologous stem cell transplant)
– donor stem cells (allogeneic stem cell transplant)
To note, patients may opt for transplant if DLBCL
– is in remission but likely to return
– is in second remission
– has not responded to other treatments.
For transplantation, usually patients use their own stem cells for DLBCL, if the patient is fit and healthy enough for this treatment.
Patients may opt for a transplant using donor stem cells in the following situations:
– lymphoma has returned after autologous transplant
– it is impossible to collect (harvest) the patient’s own stem cells
Time spent on treatment
If the patient is intensely undergoing treatment properly and correctly, perhaps every 3 to 4 months, the treatment process may last for at least 2 years.
The process all depends on other laboratory and dna examinations, including clinical examinations.
After 2 years, the doctor may shift the patient’s care to a general practitioner (family doctor).
This is because the risk of the disease returning after 2 years is small.
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Pengobatan Pasein Diffuse Large B-cell Lymphoma (DLBCL)
