A study conducted by an Inserm team ensures that staggered working hours, particularly night work, can increase the risk of developing breast cancer.
women. In 2018, more than two million new cases were diagnosed, which represents nearly 25% of all cases of cancer in the world. In recent years, various studies have been conducted to determine the factors favoring the occurrence of breast cancer. Currently, previous studies have already shown that 10% of cases are hereditary and have an origin genetic.
For the moment, various risk factors have already been identified: behavioral factors such as poor diet and hormonal factors such as taking the contraceptive pill for a very long time. For this study, carried out in collaboration between researchers from Paris-Saclay University, Inserm and INRAE, the researchers examined the effects of chronic jet lag on the development of breast tumors. Their findings were published in the scientific journal Nature Communications.
Respect the circadian rhythm
women exposed by their work to staggered rhythms over long periods would be particularly exposed to more aggressive breast cancers. “Data-reactid =” 26 “> In the As part of this study, the researchers used a mouse model that spontaneously developed breast tumors. “The animals were subjected to a continuous jet lag experimentally reproducing a shifted work rhythm (alternating day and night work or straddling day and night periods)”, Describes the press release from Inserm. Thanks to this experience, the researchers found that the disruption of the circadian rhythm had a significant impact on the development of breast tumors: “This disturbance of the sleep / wake rhythm increased the spread of cancer cells and the formation of metastases in these animal models”.
Indeed, according to the researchers, disturbances in the circadian rhythm can make the immune system “more than allowed byf ”to the spread of cancer cells by modifying the tumor microenvironment. The authors claim that the different negative effects “can be corrected by the use of a CXCR2 / CXCL5 pathway inhibitor and therefore limit the effect of circadian stress on tumor progression”. These conclusions reinforce the results of previous studies which showed that pre-menopausal women exposed by their work to staggered rhythms over long periods would be particularly exposed to more aggressive breast cancers.
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