Han Dong-geun Cha University Professor’s Team
When a person suffering from osteoporosis in old age suffers a fracture such as the hip joint due to a fall, it is not easily recovered and often leads to death. A domestic research team is expected to help by developing a bone regeneration treatment that is seven times more effective than existing ones.
The National Research Foundation of Korea (NRF) announced on the 23rd that a research team led by Professor Han Dong-geun of Cha University of Medicine has developed a zinc oxide nanoparticle biomimetic scaffold with high effects in inducing porous bone tissue regeneration.
In order for damaged bone tissue to regenerate, it needs a support that maintains its structure for a certain period of time and helps cell growth and differentiation. However, existing biodegradable polymer scaffolds induce an inflammatory response after transplantation, so it was urgent to develop a technology that can suppress it. It is urgent to develop strategies to increase the bioactivity of scaffolds for optimization of tissue regeneration and to improve cytocompatibility and function.
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The research team established a strategy to improve tissue regeneration of damaged bone tissue by introducing zinc oxide nanoparticles that help blood vessels and bone differentiation in addition to the previously developed biomimetic scaffold. The scaffold used zinc oxide nanoparticles to induce the release of nitric oxide, which plays an important role in angiogenesis. By combining alendronate, the first-line osteoporosis treatment, and bone morphogenetic protein BMP2 on the surface of nanoparticles, the osteoporotic bone regeneration ability was maximized.
The organic component extracellular matrix extracted from calf bone and organic component extracellular matrix extracted through demineralization were mixed in a certain ratio to make the actual bone tissue environment and scaffold similar. Magnesium hydroxide was added to minimize side effects caused by polymer degradation products.
The research team implanted the developed biomimetic scaffold after generating a 4mm defect in the skull of a mouse that had induced osteoporosis. After 8 weeks of the experiment, it was found that the volume of the newly formed bone tissue increased more than 7 times compared to the existing scaffold. The expression of osteoporotic factors and angiogenesis were also restored to levels similar to those of normal mice.
Professor Han said, “This proves that bone regeneration can be promoted by overcoming the harsh osteoporotic environment.”
The results of this study were published on December 29 last year in the international journal Advanced Science.
Reporter Kim Bong-soo [email protected]
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