Dr. Serafimov: Ivermectin gives great hope that we will be able to cope with the pandemic – Medicines

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He gave an interview to kmeta.bg, in which he is adamant that we are currently in a “war” and we must find the right “weapon” against COVID 19 – the biggest health crisis of the 21st century.

– Dr. Serafimov, the executive agency for medicines, officially registers in Bulgaria Ivermectin as a medicine applicable in human medicine. Is this the great hope for the treatment of COVID 19?

– The Bulgarian Executive Agency for Medicines registers Ivermectin for human use under the trade name Huvemec. Doctors in our country can now prescribe this medicine if they deem it necessary.

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Yes, Ivermectin really gives us great hope that we will be able to cope with the pandemic. The World Health Organization qualifies it as one of the most useful drugs. Scientists and physicians from the United States, the United Kingdom, the United States, South America, and Israel call on all governments to accept the needs of the United States immediately. The drug is successfully used in France, Denmark, Finland, Norway, Germany, Romania and other European countries. In the big cities of the world, where it has been used so far, there is irrefutable data that the medicine has reduced the positive cases of SOVID-19. Its role in early treatment and prevention has been proven. In Peru, for example, after a large-scale almost one-year study, mortality from COVID19 has decreased 14-fold, and cases have fallen significantly. Studies in India and Argentina have shown that the drug has a very good effect in prophylactic use.

This is really the most promising preparation against COVID 19. It has been known since 1975 and has enough experience with it. It is approved for use and has been shown to be harmless to humans

– How does ivermectin work?

– Ivermectin is thought to block the penetration of the transport protein of the virus into the cell nucleus and make it difficult to multiply. It does so in a non-specific way: the medicine blocks an enzyme, importin alpha beta, which cells use to inject the virus into themselves. Once unable to enter the cell, the virus circulates in the blood for some time, thus acting as a live vaccine. This stops its replication and unlocks the other mechanisms of infection – the inflammatory mechanism and the thrombogenic mechanism.

The drug affects various types of viruses, such as HIV-1, influenza virus, dengue virus, West Nile virus and SARS-CoV-2 / COVID 19 /. But the dosage and method of administration are extremely important, so it is important to take after a doctor’s prescription.

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– In which phase of COVID-19 infection is Ivermectin most effective?

– It can be used successfully in all phases of the disease, including prevention. But the strongest effect of Ivermectin is in the beginning, in the first few days, while the virus replicates in the cells (while the virus multiplies).

Ivermectin has nothing to do with the treatment of inflammation and throbogenesis, so it is most effective when administered before the virus has triggered a tumultuous cascade of reactions that for the most part cannot be treated.

The effect of Ivermectin for the prophylaxis of COVID-19 has definitely been proven, but again on prescription.

– Is the drug safe and what side effects could it have?

– Ivermetkin is considered a very safe drug. In France, a large group of 200 children under 15 kilograms, including six-month-old babies, has even been studied and shown to be very well tolerated.

– Ivermetkin is not yet included in the official treatment protocol for COVID-19. Do you have instructions in which cases it is appropriate to use it?

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– COVID-19 necessitated a change in our approach to treatment – a new disease for the treatment of which there was no registered drug. Evidence for the use of various drugs, including vaccines, is still being studied and sought. In such cases, it is best to use registered drugs with a change of purpose and ivermetkin is just that. It is adapted for human medicine and we have enough experience with it, we know how and when it should be applied, we also have information from research and studies in other countries.