SYNDROME polycystic ovary (PCOS) stalks many women. This endocrine disorder condition affects 5–20 percent of women of reproductive age.
PCOS needs to be treated immediately because in the long term it will develop into type 2 DM, metabolic syndrome and an increase in the incidence of endometrial cancer (uterine wall). Unfortunately, it is estimated that about 50 percent of women with PCOS are not diagnosed.
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“Regarding PCOS, we studied through research at the Yasmin Clinic, dr. Cipto Mangunkusumo (RSCM) Kencana and involved 120 research subjects, namely women of reproductive age (18-35 years) who were diagnosed with PCOS with a body mass index of less than 25 kg/m2,” said Dr. Gita Pratama, Sp. OG, Subsp. FER , M.Sc,Rep, Obstetrics and Gynecology Specialist, Reproductive Endocrinology Fertility Subspecialist, in a press release received bymerahputih.com.
dr. Primary Gita. (Photo: Personal Doc)
In his dissertation entitled Relationship between Kisspeptin, Neurokinin B and Dynorfin Levels on the LH/FSH Ratio and Polymorphism and DNA Methylation of the KISS1 Gene in Patients Non-obese Polycystic Ovary SyndromeGita said that PCOS is characterized by menstrual disorders, increased androgen hormones, and infertility. One of the findings of previous research related to obesity as a risk factor.
“Even though obesity is one of the most common risk factors, this research shows that 20–50 percent of women with PCOS have normal weight (non-obese).”
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It is estimated that the course of the disease in women who are obese and of normal weight (non-obese) is also different. The hormone that affects the female reproductive system, namely luteinizing hormone (LH) which originates from the pituitary gland in the brain, is significantly higher in non-obese women with PCOS compared to obese.
“This shows that hormonal disturbances in the brain (neuroendocrine) may be the most important mechanism in PCOS patients with normal weight,” said Gita.
Management of PCOS is to make lifestyle modifications. (Photo: Unsplash/Diana Polekhina)
He added that the management of PCOS is to make lifestyle modifications (diet and exercise). Research shows that obese PCOS patients experience symptom improvement by making these lifestyle modifications. Because PCOS patients with normal weight are more associated with hormonal disturbances, lifestyle improvements alone cannot provide significant changes in symptoms.
“This finding has triggered us to conduct research that can better understand the pathogenesis of PCOS, especially in non-obese patients, so that it is hoped that appropriate management can be developed in the future,” explained dr. Gita.
In addition, this study also revealed that there are two mechanisms that might cause an increase in the LH/FSH ratio in non-obese PCOS patients. The first is the decrease in dynorphins which is expected to affect the increase in GnRH directly in the brain.
While the second is an increase in levels of anti-Mullerian hormone (AMH), which besides directly causing egg growth to stop due to a decrease in the aromatase enzyme, it also affects the increase in GnRH. (ikh)
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2023-07-29 16:04:00
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