The science of COVID-19 vaccines and the important role of neutralizing antibodies


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Dr. Abha k sabhikhi, MD Pathology, Advisor and Mentor, SRL Technical CoE & Academics, and SRL Diagnostics analyze that antibody testing during the COVID-19 vaccination period is important for tracking and measuring the level of antibody that the vaccine produces in the body. I am.

The COVID-19 vaccination drive was launched on the foothold of the war in India on an unparalleled scale in the world. In just two months, India has vaccinated about 400 million rupees and achieved a vaccine pace of 200-300,000 rupees per day.

Keep the spirit of vasudhaiva kutumbakam (The world is one family) Japan, which is the center of the vaccination mission, has gained international credibility by supplying more than 5.96 million rupees of “Made in India” vaccine to 73 countries around the world.

Increasing self-satisfaction of COVID

India is also facing a new wave of COVID-19, despite the daily vaccination of Raku. The main reason for the new wave is that as vaccines became visible, people tired of COVID began to act negligently, believing that vaccination was a surefire solution to the public health crisis. .. As a result, people have stopped following appropriate COVID measures.

Also, many people after vaccination are neglecting COVID-19 prophylaxis. It is important for the medical community to raise awareness of the true role of vaccination, as this can prove dangerous and counterproductive to all vaccination efforts.

Need to be vigilant despite vaccination

Finding a vaccine for any disease is a complex process and requires years of scientific research and testing. Creating a COVID vaccine at record speed is certainly a great achievement for humankind. But the science of illness and vaccination is not as simple as we would believe. Here are some reasons why people need to continue to act properly on COVID.

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Given the vast population inoculated, it is premature to say how effective the vaccine is in neutralizing the infection and containing its spread. The effectiveness of the vaccine against all variants of the virus that spreads around the world is also completely unknown. In addition, the immunity gained by the vaccine has not yet been definitively tested.

Understanding how the COVID-19 vaccine works

The COVID-19 vaccine helps our body develop immunity to the virus that causes COVID-19 without getting sick. Different types of vaccines work in different ways and provide protection. However, all types of vaccines leave the body with a supply of “memory” B and T lymphocytes, and remember how to fight the virus in the future. After vaccination, it usually takes about two weeks for the body to develop an immune response. Therefore, you may be infected with the virus that causes COVID-19 immediately before or after vaccination. In such situations, the individual develops the disease because the vaccine did not have enough time to provide protection.

The Government of India has approved two vaccines. Currently, the vaccination drive in India administers two doses of vaccine with a gap of 4-8 weeks, depending on the vaccine to be injected. Much depends on the quality of the antibodies developed after each administration of these vaccines. Vaccines administered in India use total virion-inactivated Vero cell technology to introduce laboratory-isolated dead coronavirus into the body, or are extracted from coronavirus and added to common cold adenovirus. Introduce a mixture of spice proteins.

After being injected into the body, these foreign viral components stimulate the human immune system to activate antibodies. In the face of a real COVID infection, the antibody attaches to the viral cells, marks them for killing, and prevents them from infecting healthy cells. Therefore, the production of high quality antibodies is essential to successful vaccination.

Need for antibody testing after vaccination

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Despite vaccination, there are several reasons why the COVID-19 vaccine may not induce sufficient antibody production. Known factors associated with a weakened immune response after vaccination include old age, weakened immunity, various comorbidities, regular post-vaccination drinking, genetic background, and even previous infections. There is.

So how can we know if vaccination has led to the proper production of antibodies? It is through antibody testing that the level of antibodies produced in the body after vaccination can be measured. The test should be done 2 weeks after each round of vaccination.

Which antibody test works?

The development of neutralizing antibodies that prevent the disease should be checked. This is best done with a new antibody test, also known as the SARS-COV-2 peplomer antibody test, which detects neutralizing antibodies. This should not be confused with the usual Total and IgG antibody tests used primarily in serological studies to track the spread of COVID within a population for epidemiological purposes.

The SARS-COV-2 peplomer antibody test is designed to determine the level of protective immunity achieved after vaccination. This test determines antibodies against viral peaplomers that bind to human cells and invade the body. The production of neutralizing protective antibodies against the SARS-CoV-2 peplomer best correlates with the individual protection gained after vaccination. Basically, this test answers whether an individual has protective antibodies that fight the infection when exposed to the virus.

Important role of antibody testing

New antibody tests have an important role to play at the individual and community levels. Testing at various stages of vaccination, when performed at the appropriate sample size for the individual, can assess the effectiveness of the vaccination drive. You can identify potential shortages and enhance your program.

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At the individual level, knowledge of defensive immunity is reassuring and gives confidence to the process. Detecting low levels of immunity after vaccination helps people take appropriate steps to consult their healthcare provider and continue to recognize the appropriate means of COVID.

In addition, individuals with high levels of neutralizing antibodies may be potential candidates for plasma donation to severely infected COVID patients. Clearly choosing a specific and appropriate antibody test after vaccination is important in the fight against a pandemic.

The science of COVID-19 vaccines and the important role of neutralizing antibodies

Source link The science of COVID-19 vaccines and the important role of neutralizing antibodies

Gynaecology or gynecology is the medical practice dealing with the health of the female reproductive system. Outside medicine, the term means “the science of women”. Its counterpart is andrology, which deals with medical issues specific to the male reproductive system. Read More About Gynecologist in Indore.

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