A new study shows that the new corona virus COVID-19Certain secretions relieve pain, which may explain the reason for the appearance of few or no symptoms in nearly 50% of the infected people, although they are able to spread the disease.
According to researchers, including Rajesh Khanna, from the University of Arizona in the United States, nearly half of the transmission of the Coronavirus COVID-19 It occurs before symptoms appear, and 40% of infections COVID-19 Without symptoms.
Khanna said: “It was logical that it might be the cause of the continuous spread of the Coronavirus COVID- 19 Is that in the early stages, you do not feel sick but rather you are going well as if you did not have the virus, because there is no pain.
In the research, published in the journal PAIN Scientists have raised the possibility that pain was one of the early symptoms of … COVID-19 , May be reduced by elevated coronavirus protein because it silences ‘pain signaling pathways’ in the body“.
Early in the epidemic, scientists demonstrated that the spiky protein of the new Coronavirus uses the ACE receptor. (ACE2) For human cells to enter the body.
Later in June, two studies published indicated that there is another future called “Nirubilin 1”.neuropilin-1 As a second receptor for the Coronavirus, the researchers said.
“This caught our attention because our lab for the past 15 years has been studying a complex set of proteins, pathways, involved in treating pain down the stream of Nairobi,” Khanna explained.““So we realized that this may mean that the spike protein, which is also present in the Coronavirus, may be involved in some kind of pain treatment.”“.
According to the site TheHealthSite One of the biological pathways through which the body senses pain is a protein called vascular endothelial growth factor A (VEGF-A) Which plays an essential role in the growth of blood vessels, adding that this protein has recently been linked to the Coronavirus COVID-19
And his research team found, that the prickly corona virus protein binds to nerropylene in the same site exactly as a protein VEGF-A Scientists have also examined neurobilin as a new target for non-opioid pain relief.
“We are advancing the design of small molecules against neurobilin, especially natural compounds, which could be important for pain relief.”“.
He said we have a pandemic, and we have an opioid epidemic, they collide, our findings have enormous implications for both of them inform us about the spread of the Corona virus, but Corona Virus COVID-19 Also made us look at nerropylene neuropilin But it is a new, non-opioid way to fight the opioid epidemic.
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