People who have reported side effects such as fever, chills, or muscle aches from Pfizer / BNT and Moderna COVID-19 (coronavirus disease 2019) vaccines, are likely to have a stronger antibody response.
A study published in JAMA Network Open on the 21st pointed out that compared to just pain or rash at the vaccination site or the absence of symptoms, the above symptoms and stronger antibodies after vaccination are related to the reaction.
“In conclusion, these findings support the definition of post-vaccination symptoms as an indicator of vaccine efficacy,” said the researchers from Columbia University, the University of Vermont and Boston University in New York. They report and strengthen guidelines for vaccination boosters for the elderly. “But even though some people may have mild local side effects or no symptoms, the vaccine still triggers a strong immune response in them. Almost all of the study participants had positive antibody responses after completing 2 doses of Pfizer / BNT or Moderna vaccine.
“I don’t want patients to say to me, ‘Oh my god,'” said William Schaffner, professor in the Division of Infectious Diseases at Vanderbilt University Medical Center and medical director of the National Foundation for Infectious Diseases. Ah, I have no reaction, I have no pain in my arm, I have no fever and the vaccine does not work at all. “I don’t want them to come to this conclusion.” Schaffner pointed out, “It’s more to reassure those who are reactive, although (the vaccine) made them sick a little, their immune systems actually responded well.”
“For years, there has been a lot of speculation that people who respond more strongly to the vaccine may actually have a stronger immune response. These data appear to support that,” said Schaffner, who was not involved in the new study.
The researchers analyzed 928 adults who reported symptoms after receiving the Pfizer / BioNTech or Moderna COVID-19 vaccine and presented dry bloodstains to test for antibodies. Most of the subjects were white adults with a mean age of 65 years.
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