EMBARGOED UNTIL 12/27 AT 8 PM
BARCELONA, 27 Dic. (EUROPA PRESS) –
Researchers from the Universitat Pompeu Fabra (UPF) and the Hospital del Mar Research Institute have shown in a study that intradermal vaccination with the JYNNEOS vaccine against smallpox is the “best” option to protect people with HIV from contracting the virus. monkeypox, the university reported in a statement this Wednesday.
The ‘Journal of Medical Virology’ has published the results of the work in which they determine that those people with a low level of CD4 T cells, a type of white blood cell “essential to adequately combat new infections”, need a booster dose 28 days after the first dose to compensate for your immunosuppressed state.
The activity of T cells, which are responsible for the response against pathogens, homeostasis and memory of the immune system, of HIV-1-infected individuals, whose viral load was controlled by antiretroviral therapy, increased after vaccination with the JYNNEOS smallpox vaccine, while their T cell response was equivalent to that of healthy control individuals.
Among people living with HIV infection, there is a risk group of immunologically non-responders (called INR) who control their viral load with antiretroviral therapy, but only partially recover their count. of CD4 T lymphocytes.
These INRs may require a booster dose 28 days after the first vaccination to generate an efficient T cell response and be protected against monkeypox.
These findings “underscore the importance” of conducting specific studies on the immune response of people with HIV, especially those who have a lower number of CD4 white blood cells.
2023-12-27 19:04:00
#Smallpox #vaccine #protects #monkeypox #people #HIV #study #finds
