A recent Swedish study revealed that a high level of caffeine in the blood may reduce the amount of body fat a person carries and reduce the risk of developing type 2 diabetes, confirming previous observational studies.
Researchers noted earlier that drinking 3 to 5 cups of coffee per day, which is a rich source of caffeine, is associated with a lower risk of developing type 2 diabetes and cardiovascular disease, as a cup of coffee contains, on average, about 70 to 150 mg of caffeine. .
Because these studies are observational, a research team from the Karolinska Institutet in Sweden was interested in finding evidence to confirm this, so they used “Mendelian randomization”, a technique used to find genetic evidence that supports a particular result.
The researchers looked at the role of common genetic variants of two genes involved in how quickly caffeine is metabolized in the body, CYP1A2 and AHR, in nearly 10,000 people in Europe.
They found that people with genetic variants associated with a slower metabolism of caffeine drank, on average, less coffee, yet had higher levels of caffeine in their blood, compared to people with fast caffeine metabolism who could reach or maintain the levels needed for its stimulant effects.
The results of the analysis also showed that the genetic causes of high levels of caffeine in the blood were associated with low weight (body mass index) and body fat, and were associated with a lower risk of developing type 2 diabetes.
coffee consumption
The researchers believe that their findings explain, at least in part, the inverse association between coffee consumption and reduced risk of developing type 2 diabetes, according to the study published Tuesday in the BMJ Medicine journal, “British Medical Journal.”
“Our findings can be seen as evidence of what has been shown in observational studies that caffeine without calories may play a role in reducing the risk of obesity and type 2 diabetes,” they said.
sugar and fat
In turn, Dr Katharina Koss, senior lecturer in diabetes and obesity at the University of Exeter, said the research showed health benefits for people with high levels of caffeine in their blood, but she added: “I wouldn’t recommend drinking more coffee, which was not the purpose of this research.” “.
She also said, “Any caffeinated beverages that contain sugar and fat will offset the positive effects.”
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