Home » today » Health » Scientists at the University of California, Riverside and Yale University have reported the first high-quality nuclear genome sequence and assembly of the tick-borne pathogen Babesia duncani, which causes the malaria-like disease babesiosis. They also determined the 3D genome structure of the pathogen, highlighting new classes of multigene families that allow the parasite to avoid the host immune response. The team identified leads for the development of effective therapies against the disease, including the pipeline of small molecules pyrimethamine.

Scientists at the University of California, Riverside and Yale University have reported the first high-quality nuclear genome sequence and assembly of the tick-borne pathogen Babesia duncani, which causes the malaria-like disease babesiosis. They also determined the 3D genome structure of the pathogen, highlighting new classes of multigene families that allow the parasite to avoid the host immune response. The team identified leads for the development of effective therapies against the disease, including the pipeline of small molecules pyrimethamine.

Ticks have always been a source of concern for people venturing into the great outdoors, but now researchers are warning about a lesser-known tick-borne disease called babesiosis. This disease, caused by microscopic parasites that infect red blood cells, has been on the rise in recent years and can be fatal for those with weakened immune systems. With cases spreading across the United States, it’s important to understand the symptoms, risk factors, and prevention methods for babesiosis. In this article, we’ll take a close look at what researchers are saying about this growing threat and explore how you can protect yourself and your loved ones from babesiosis.


As the weather warms up and more people head out for hikes and outdoor activities, the risk of tick bites and the diseases they can transmit becomes a greater concern. One such disease is babesiosis, a malaria-like illness caused by the Babesia parasite and spread primarily by ticks. Recent research has shown an increase in tick-borne diseases globally, likely due to climate change and other environmental factors. Babesia parasites can be particularly threatening to both humans and animals, infecting and destroying red blood cells.

In a new study published in Nature Microbiology, scientists from the University of California, Riverside, and Yale University report the first high-quality nuclear genome sequence and assembly of the Babesia duncani pathogen, and determine its 3D genome structure. Their findings reveal that the parasite has developed new classes of multigene families, allowing it to avoid host immune responses and enhancing its pathogenicity and virulence. The study also identifies promising leads for the development of more effective therapies for treating human babesiosis caused by B. duncani, a neglected species until now.

Though healthy individuals may not show symptoms of babesiosis, a compromised immune system can lead to flu-like illness. More severely, babesiosis can cause high parasite burden, severe pathology, and even death, particularly in older and immunocompromised individuals. Diagnosis can be complicated, as skin manifestations of babesiosis are rare and difficult to separate from Lyme disease, which is also transmitted by the same tick.

The authors of the study emphasize the importance of being aware of ticks when spending time outdoors, particularly in wooded or grassy areas. They also urge individuals to inform their physicians if they go hiking, as babesiosis can be easily misdiagnosed. Further research is planned to investigate how B. duncani survives in ticks and to develop novel strategies for controlling the parasite in ticks.


In conclusion, the threat of babesiosis is real and growing, and researchers are urging the public to take precautions to protect themselves and their families. With a variety of simple measures including wearing protective clothing, using tick repellent, and conducting thorough checks for ticks after outdoor activities, it is possible to greatly reduce the risk of contracting this dangerous disease. With continued research and education efforts, we can work towards a future where babesiosis is no longer a major health concern. As always, prevention is key, and we must all do our part to stay safe and healthy in the face of this ticking time bomb.

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