December 21, 2022 – 08:58
Have people more frequently exposed to non-typhoidSalmonella an increased risk of colon cancer? Researchers from Leiden University Medical Center (LUMC) and the University of Illinois jointly conducted a study to find an answer to this question. The first results of the study suggest that not typhoid Salmonella it may increase the risk of colon cancer by contributing to one stage in the multistep process of cancer formation. The researchers’ findings were published in Cell Reports Medicine.
One Salmonellathe infection is a common bacterial disease affecting the intestinal tract. People are often exposed to non-typhus Salmonellamainly through livestock and through the consumption of foods derived from them, such as eggs and meat.
Cheering Salmonella – which causes typhoid fever – infects 10-20 million people each year and causes an estimated 130,000 deaths worldwide. Non-typhoid Salmonella infections are more common and less fatal, but lead to an estimated 153 million cases of diarrhea and vomiting and 57,000 deaths worldwide each year.
Salmonella and cancer development
Cheering Salmonellathe infection has previously been associated with gallbladder cancer. This is because the bacteria allow for one step in the multi-step process of cancer formation. Epidemiological studies have also found severe non-typhoid forms Salmonellainfections have been associated with an increased risk of developing colon cancer.
“A non-typhoid Salmonellathe infection is often not noticed by ourselves, but this infection is recognized by our immune system! Our study examined whether or not typhoid is mild and undetected Salmonellainfections increase the risk of colon cancer. The idea behind this is that with repeated mild bacterial infections, a bacterium is more likely to invade and manipulate cells that have already gone through several steps in cancer development due to a previous infection. Those cells are, so to speak, waiting for that extra “move”. Salmonella offers,” said Virginie Stévenin, postdoctoral researcher at the grandchildren’s workshop.
Search results
To find out if after exposure to non-typhoid Salmonella there is an increased risk of colon cancer, the researchers measured the levels of antibodies against non-typhoid Salmonella in more than one hundred human blood samples to determine the percentage of undetected infections. The researchers found that people who had developed colorectal cancer were also more often exposed to mild ones Salmonellainfections. In intestinal tumors of mice, after infection, Salmonella are detected.
“We also found that more mild infections increased the growth rate of these intestinal cancers. Moreover, it turned out Salmonella in a cell culture model, infecting cells with the potential to more rapidly transform into fully transformed tumor cells, thus further promoting cancer formation,” says Jacques (Sjaak) Neefjes, professor at LUMC.
In short, a risk factor
Jun Sun, a professor at the University of Illinois at Chicago, concludes: “These experiments suggest that not typhoid Salmonella infections can increase the risk of colon cancer by affecting one stage in the multistep process of cancer formation. Completely avoiding such infections is difficult, as is not typhus Salmonella common in livestock and our food. However, exposure to bacteria can be reduced with good hygiene practices when handling and preparing food.
Read the original article Cell Medicine Reports.
Source: LUMC
Editorial Medicalfacts/ Janine budding
I studied physiotherapy and health business administration. I am also a Registered Independent Customer Service Representative and Informal Service Broker. I have a lot of experience in various positions in the healthcare sector, the social sector and the medical and pharmaceutical industry, nationally and internationally. And have broad medical knowledge of most healthcare specialties. And of the care laws by which care is regulated and funded. Every year I attend most of the major medical conferences in Europe and America to keep my knowledge up to date and to keep up with the latest developments and innovations. I am currently attending a Masters in Applied Psychology.
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