Exclusive “Mystery of Heartbeat Speed ​​Revealed, Taiwan Research Team Leads the World to Solve It-News Fax-Free Health Network

The team of Hu Yufeng, a cardiologist from Beirong, a professor at Yangming Jiaotong University and an associate researcher at the Institute of Biomedical Sciences, Academia Sinica, has solved the mystery of heart rate. (Provided by Yangming Jiaotong University)

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[Reporter Yang Yuanting/Rapporto Taipei]Why is my heart rate suddenly fast and slow? It has always been an unsolved mystery in the scientific community, but it was solved by the team of Hu Yufeng, a cardiologist in Beirong, a professor at Yangming Jiaotong University and an associate researcher at the Institute of Biomedical Sciences, Academia Sinica. The team discovered a new mechanism for sugar metabolism to regulate heartbeat. After comparison, it was found that ‘aldolase C’, which is responsible for the sugar metabolism gene, regulates the rate of heartbeat and aims to supplement The energy of glycolysis can prevent or cure slow or fast heartbeat. The team is developing related drugs or non-drug treatments. It is expected to replace the pacemaker that needs to be surgically implanted.

Encountering a crush is just like running, your heart rate will increase and your heart rate will be relatively slow while sitting and resting. The academic community disagrees on the reason for the speed of the heart rate. The main reason is that it is difficult to obtain or isolate the human or animal heart cells that are beating.The treated heart rhythm cells, which regulate the heartbeat, were compared with the entire genotype and the analysis found that the cells were strongly related to sugar metabolism.

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The team further analyzed and found that the heart rhythm cell’s aldolase C gene plays a key factor and further confirmed that aldolase C regulates sugar metabolism, thereby regulating the rate of heartbeat. by Hu Yufeng opens a new door for related research. .

In the human metabolism network, glycolysis usually starts with glycolysis and the initiation of glycolysis depends on the aldolase gene in the cell. Aldolase is divided into three types of ABC. Aldolase C is the least known. Hu Yufeng said the relevant mechanism has now been discovered. In the future, heart rate may be regulated by metabolism or aldolase C supplementation. It is even planned to use non-invasive non-drug therapy for its preventive treatment to reduce the risk of health risks due to slow or heartbeat rapid.

Since aldolase C is cell-specific, if there are related drugs in the future, it is expected to replace the sigmoid blocker commonly used in the clinical treatment of tachycardia. Hu Yufeng said that although many people with tachycardia are not life-threatening, it will make them feel uncomfortable., Current prescriptions are mainly taking sigmoid blockers and sigmoid blockers mainly block the action of adrenaline by blocking the β1 and β2 receptors, thus slowing the heartbeat, but almost all the cells in the body are blocked.There are β1 and β2 receptor cells, so it will bring more side effects, such as general weakness after taking, and asthma patients cannot use it.

As for how to integrate aldolase C in the future? Hu Yufeng said the team is still exploring possible gene therapy methods, but is also looking into whether it can regulate sugar metabolism or supplement glycolysis energy by changing daily habits such as diet and exercise.

The study was published on the cover of Circulation Research, a leading cardiac medicine journal with an IF of 23.