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Causes of Stevens Johnson Syndrome, A Rare Skin Disease

KOMPAS.com – Steven Johnson Syndrome may not be familiar to most people. This syndrome is a rare disease.

Sindrom stevens johnson is a rare disorder that affects the skin, mucous membranes, genitals and eyes.

Stevens-Johnson syndrome is usually caused by an unexpected adverse reaction to certain medications. Sometimes it can also be caused by an infection.

Stevens Johnson syndrome usually begins with flu-like symptoms, then is followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off.

Sindrom Stevens Johnson is a medical emergency that requires hospital treatment.

Treatment is done to identify the underlying cause, control symptoms and prevent complications.

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What caused it?

In children, sindrom stevens johnson usually triggered by a viral infection, such as:

  • mumps
  • flu
  • herpes simplex virus, which causes sores
  • Coxsackie virus, which causes Bornholm disease
  • Epstein-Barr virus, which causes glandular fever
  • bacterial infection.

In adults, Stevens-Johnson syndrome is often caused by an adverse drug reaction.

The drugs that most commonly cause Stevens Johnson syndrome are allopurinol, carbamazepine, lamotrigine, nevirapine, phenobarbital, phenytoin, sulfamethoxazole, sertraline, and sulfasalazine.

On the other hand, there are several risk factors that trigger this syndrome. The following are the risk factors:

  • viral infections such as herpes, hepatitis, viral pneumonia or HIV
  • a weakened immune system as a result of HIV or AIDS, autoimmune conditions, such as lupus, or certain treatments, such as chemotherapy and organ transplants.
  • family history of Stevens-Johnson syndrome.

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