Zheng Shaobin, director of the Organ Transplant Center at Taichung Tzu Chi Hospital, said that the simultaneous use of immunosuppressive drugs and oral antiviral drug Paxlovid will reduce the metabolism of immunosuppressive drugs and increase the plasma concentration of immunosuppressive drugs, which it will lead to kidney function damage, increased blood pressure and increased blood pressure Insomnia, headache and other symptoms. (Photo by journalist Ou Sumei)
[Reporter Ou Sumei/Taichung Report]He Nan, 46, received a liver transplant and recovered well after the surgery. other symptoms after taking antiviral drugs, fortunately to seek medical attention in time. Zheng Shaobin, director of the Organ Transplant Center at Taichung Tzu Chi Hospital, reminded patients that the interaction of anti-rejection drugs taken by organ transplant patients with antiviral drugs for new coronary pneumonia may be life-threatening. Keep track of blood levels and clinical conditions.
Mr. He regularly took immunosuppressants (anti-rejection drugs) and was diagnosed with new coronary pneumonia in late September. After taking the oral antiviral drug Paxlovid prescribed by the clinic’s doctor for 5 days, he developed persistent, tossing and turning headaches, loss of appetite and other symptoms. She endured the pain until the home isolation period expired and went to the liver transplant clinic at Taichung Tzu Chi Hospital for medical treatment.The evaluation and examination found that the concentration of immunosuppressive drugs exceeded 10 times the upper limit of the normal value.
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Zheng Shaobin said that since the commonly used immunosuppressants and the oral antiviral drug Paxlovid have the same metabolic enzymes in the human body, taking them simultaneously will reduce the metabolism of immunosuppressive drugs and increase the plasma concentration of immunosuppressants. Excessive drug concentration can cause neurological symptoms such as impaired kidney function, increased blood pressure, insomnia, headache, tremor, and paraesthesia, and can also cause secondary infections due to excessive immunosuppression. Serious side effects of the drug can be fatal and should not be ignored. .
Zheng Shaobin said many liver transplant patients had previously been diagnosed and, prior to using oral antiviral drugs, contacted team doctors in advance to consult about immunosuppressant dose adjustment and collaborated with blood draws for monitor plasma concentrations of drugs. He Nan thought he informed the clinic doctor that this was a patient who had been taking immunosuppressive drugs for a long time, and later did not contact the transplant team.There was a severe drug interaction due to the differences in yin and yang. and the concentration of the drug increased more than 10 times.
Zheng Shaobin pointed out that in order to ensure the safety of patients after organ transplantation, it is recommended to temporarily stop immunosuppressive drugs during the 5-day course of the oral antiviral drug dose. After organ transplantation, patients infected with the disease should take the initiative to contact the physician of the original transplant team to consult on the adjustment and tracking of concentrations and clinical conditions related to anti-rejection drugs during the course antiviral drugs, in order to restore health with peace of mind and safety.
The new coronal pneumonia epidemic has continued to this day and around 6.9 million people have been diagnosed in Taiwan. The Ministry of Health and Welfare also recalled that the oral antiviral drug Paxlovid interacts with a variety of drugs. In addition to the 10 drug categories that are contraindicated, there are also 35 drug categories that need to be closely monitored.
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