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Advancements in Diagnosis and Treatment of Childhood Tumors

[Voice of Hope August 12, 2023](Editor: Li Zhi) Currently, malignant tumors have become the second leading cause of death among children. According to a survey by the Children’s Tumor Detection Center in Mainland China, from 2018 to 2020, there will be a total of 121,145 children in mainland China. children and adolescents were diagnosed with tumors.

Children’s tumors are hidden in the early stage, with the characteristics of rapid onset, rapid progression, and easy metastasis. Parents should pay close attention to the four high-risk tumors in children: neuroblastoma, brain tumor, malignant lymphoma, and Wilms tumor.

Fortunately, after early standardized diagnosis and treatment, more than 70% of children with these four types of high-incidence tumors in children can be cured.

fever (pixabay)

Neuroblastoma has always been known as the “king of tumors in children”. The peak age of onset is from 0 to 5 years old. The early symptoms of children are usually fever, emaciation, and local tumors. With the continuous updating of diagnosis and treatment methods, the “king of childhood tumors” is no longer scary.

In the face of newly diagnosed neuroblastoma, doctors can accurately diagnose the location of neuroblastoma, degree of bone marrow infiltration, extent of bone marrow metastasis, and genetic characteristics through new technologies such as radionuclide technology, small residual tumor detection, and genetic testing. , evaluation, so as to carry out “individualized diagnosis and treatment” for children.

For advanced relapsed and refractory neuroblastoma, at present, the multidisciplinary diagnosis and treatment (MDT) team dynamically revises the diagnosis and treatment plan and model, and uses chemotherapy, surgery, radiotherapy, autologous stem cell transplantation, and GD2 monoclonal antibody treatment. The 5-year event-free survival (EFS) rate of children with relapsed and refractory neuroblastoma was increased by 15%, and the 5-year overall survival rate (OS) was increased by 14%, achieving good curative effect.

At present, the incidence of brain tumors in children in China is rapidly increasing year by year. About 7,000 children in mainland China are diagnosed with brain tumors every year. Common types of brain tumors in children include medulloblastoma, craniopharyngioma, astrocytoma, Ependymoma and glioblastoma etc.

The peak age of onset of brain tumors in children is between 5 and 8 years old. Early common symptoms in children are headache, vomiting, visual disturbance and so on. Because children’s bodies are in the development stage and have the characteristics of vigorous metabolism and strong bone marrow regeneration ability, radiotherapy can usually achieve better results. “Both benign and malignant brain tumors in children can be cured, such as pilocytic astrocytoma, with a 5-year survival rate of 97%. For highly malignant tumors, such as medulloblastoma, the 5-year survival rate can reach 60%-70%. ” Zhao Qiang introduced.

Childhood malignant lymphoma is a malignant tumor that occurs in lymphatic tissue, and is mainly divided into two categories: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. The peak age of onset of this disease is 4-7 years old. The early symptoms of children are often enlarged lymph nodes, general fatigue, and weight loss. Because the early symptoms and signs are not obvious, they are often treated as other diseases, and the misdiagnosis rate can reach more than 60%.

Although the vast majority of non-Hodgkin’s lymphoma in children is highly malignant, with the development of medical technology, the survival rate has increased significantly in recent years, approaching 80%. Hodgkin’s lymphoma is relatively low in malignancy, and the cure rate can be expected. Up to about 90%.

Weakness (pixabay)

Wilms tumor is the most common malignant tumor of the urinary system in children, and the incidence rate of boys and girls is roughly equal. The peak age of onset in children is 3 to 5 years old, and the early symptoms are common abdominal mass and hematuria.

Abdominal mass is the most common symptom of Wilms tumor in children. Parents can find it by palpation. Generally, the mass is located below the costal margin on one side of the child’s abdomen. 1/3-1/2 of that.

The treatment of Wilms tumor mainly involves surgery, radiotherapy, and chemotherapy. The treatment effect of Wilms tumor is the best among all childhood tumors. If it is detected early and received standardized treatment, the overall cure rate can exceed 90%.

Early detection of childhood tumors with the “one-minute cancer prevention check-up” method

Some children are young at the time of onset and cannot accurately describe their symptoms through language. Therefore, parents play a decisive role in early detection of childhood tumors.

Parents should use the “one-minute cancer prevention physical examination” method after the child is bathed or in a deep sleep, and follow the eight-character formula of “head, neck, shoulder, arm, abdomen, leg, back and yin” to touch and check the child’s whole body one by one, paying special attention to the examination of subcutaneous soft and hard lumps , If you find a mass in the abdomen and limbs, you should go to the hospital for a professional examination as soon as possible.

Children with a family history of cancer, genetic disorders, long-term exposure of parents to certain chemicals (paints, petroleum products, solvents, pesticides), mothers who were exposed to ionizing radiation during pregnancy, or who took certain hormonal drugs can develop cancer Risks will increase. Yan Jie suggested that for children with high risk of cancer, parents should take their children to professional hospitals for physical examination on time. Usually, according to the incidence of childhood tumors, it is recommended that parents take their children to do B within 1 year after birth and when the child is around 3 years old. Ultra-screening, early detection of disease and early diagnosis and treatment.

Editor in charge: Li Zhi

This article or program is edited and produced by Voice of Hope. Please indicate Voice of Hope and include the original title and link when reprinting.

2023-08-12 07:51:04

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