The World Health Organization found that global arthritis patients dropped from 70 years old to 40 years old, which is a very serious health warning. The impact of arthritis and other joint problems on life cannot be ignored. Some scholars believe that it can be juxtaposed with cancer and cardiovascular diseases. For one of the most terrible health killers!
In order to reduce the probability of joint degeneration, from the earliest chondroitin, glucosamine, to the reddest type II collagen (UC2/UCII) in recent years, and the proteoglycan (NEM eggshell membrane/salmon Nasal cartilage extract), products that improve arthritis and repair cartilage are constantly being introduced, but what is type II collagen? What are the functions of proteoglycans? The following treatment days are organized for everyone.
What is Type II Collagen?
What is Type II Collagen? In fact, UC-2 / UC-II, which has been very popular in recent years, is the English abbreviation of “Undenatured Collagen Type II” (Undenatured Collagen Type II). Generally, the structure of collagen will be destroyed and “denatured” during extraction, so “Non-denatured” means to retain the original triple-helix structure of collagen, which can achieve better application to the joints of the eater.
What does type II collagen have to do with arthritis?
Sometimes joint inflammation turns out to be because our immune system attacks our own body! Our articular cartilage wears away when it moves, and the type II collagen of the cartilage produces fragments that may be viewed as foreign by immune cells, resulting in an inflammatory response in the joint, which may not only cause discomfort, but also speed up the joint. Apoptosis of chondrocytes.
If you take non-denatured type II collagen, the immune vanguard “T cells” in the lymph nodes of the gastrointestinal tract will be exposed to the complete structure of type II collagen, which can generate memory and help train “can recognize type II collagen” In this way, the immune cells will be less likely to be “hostile” to attack the collagen fragments after the wear of the articular cartilage. Therefore, the inflammatory response will decrease, and the chance of premature apoptosis of articular chondrocytes due to inflammation will be reduced. situation.
Empirical Efficacy of UC-2/UC-II
In a study on UC-2 / UC-II and osteoarthritis published in
It was found that the subjects who took 40mg UC-2 / UC-II per day were better than the group taking glucosamine + chondroitin in terms of pain, stiffness, and physical function, and significantly improved the discomfort symptoms of osteoarthritis.
Further reading: Which is more effective, UC-II or glucosamine?Type II collagen can improve inflammation and help cartilage regeneration
What are proteoglycans?It forms the cartilage matrix together with collagen
Proteoglycan (proteoglycan) presents a plume shape, and through its strong water absorption capacity, it achieves the swelling of the skin and the strength of the cartilage. In cartilage, proteoglycans form the matrix of cartilage with type II collagen, hyaluronic acid and water. Proteoglycans combine with chondroitin, keratin, etc. to form a feather-like structure; this structure is extremely water-absorbing, and when it fills in the collagen grid-like structure and absorbs water, it will produce a strong supporting force, Support the strength of cartilage.
The relationship between proteoglycans and arthritis
A study “Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product” in the American journal “Modern Research in Inflammation” pointed out:
Joints can become inflamed and painful, partly because of the excessive secretion of the following 3 “joint cytokines”:
They are like security alarms. When pathogens invade, these three hormones will initiate an inflammatory response to fight, but if they are secreted too much, they may damage our own cartilage and bones. The study pointed out that the proteoglycan extracted from the eggshell membrane can reduce the above three hormones, effectively stop their damage to cartilage and bone, and achieve the benefit of slowing down the wear and tear of cartilage.
In addition, the C-terminal part of proteoglycan has a binding region similar to Epidermal Growth Factor (EGF), which can promote the synthesis of collagen and hyaluronic acid, both of which are the matrix of cartilage. Sugar, helps cartilage hyperplasia.
Further reading: How to eat eggshell membrane (proteoglycan)? How to increase the effect? Understand the benefits and eating methods of eggshell membrane in 3 minutes
Demonstration of Proteoglycan Action on Arthritis
In 2016, some scholars recruited 25 human subjects suffering from knee osteoarthritis-related pain and stiffness. The subjects took 500 mg of NEM (eggshell membrane, containing proteoglycan) once a day for 4 months. Week. Experiments have found that taking 500 mg of NEM once a day can quickly (10 days) significantly reduce pain and stiffness, and this effect will continue to improve within 30 days, and the safety of patients is also affirmed.
Reminders for treatment days: be careful of allergic reactions
Type II collagen may be taken from salmon, while NEM is taken from eggshell membranes. Both sources may cause allergic reactions. It is recommended to consult relevant experts before making a decision when using them.
Treatment day extension recommendation: Osteoarthritis rejuvenates! Is there evidence for the function of the eggshell membrane? Maintaining joints is better than glucosamine?
Have a good chat and heal your healthy life
參考資料：〈Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product〉
Image source: 123RF
