go run University of Buffalo Scholars A study whose results show the possibility of reversing the aging process in muscle cells. Aging in muscle cells occurs when the cell’s ability to divide and repair is reduced or diminished, which is known as cellular aging. The study found that by overexpressing a specific protein called NANOG, the cell could be restored to a different state to reverse aging.
cellular aging
Cellular aging occurs when cells reach a point where they are no longer able to repair themselves and cannot divide.The genetic material within the cell becomes unstable, leading to cellular deterioration and disease. And then the whole body stops regenerating cells over time.
different technology
Previous attempts to reverse aging in cells have focused on returning the cell to a stem cell-like state. But the new technology, invented in the latest study, takes a completely different path, literally helping the cell to return to its remodeling process to regain full functionality.
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Scientists have discovered an important role for a protein known as NANOG in the aging of human muscle cells, which by overexpressing it, or in other words by energizing it, was able to reverse age-related cell degradation and increase the repair mechanisms of the muscle. Cell DNA.
Cellular rejuvenation
More intriguingly, the researchers explain, when NANOG was overexpressed in prematurely aged lab mice, the number of muscle stem cells increased, reconfirming the results of the human muscle cell laboratory study, implying that NANOG was overexpressed and gives it properties of regeneration and repair of aging cells.
The lead researcher of the study, Professor Stelios Andreades, said that skeletal muscle is a highly regenerative organ that makes up about 45% of the total body mass and contributes to the ease of skeletal movements and the regulation of metabolism.
The process of renewal, repair or new growth in the organism in muscle tissue is carried out by the proliferation of muscle fibers, and therefore when the original muscle efforts or the basic beginnings of muscle growth are activated, they multiply, differentiate and contribute to the regenerative growth of damaged muscle fibers.
Indefinite playback
And Professor Andradis pointed out that one of the challenges his research team faces at the current stage is that the NANOG protein did not multiply indefinitely, as the cumulative number of cells after about 20 or 25 days of overexpression witnessed one. state of stability, explaining that this problem is not the last in the search for ways to rejuvenate, but it sets a cornerstone that motivates us to continue to discover other ways to overcome the aging process indefinitely.
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