Bogordaily.net – The medical world is again delivering good news, especially in the field of kidney transplantation. Three children with a rare genetic disease successfully underwent kidney transplant surgery without giving them immune-suppressing drugs or drugs immunosuppressant.
Generally, organ recipients must take medication immunosuppressant for the rest of his life to prevent the immune system from rejecting new organs in his body.
However, the side effect of these drugs is to increase the risk of infection and cancer. In some cases, immunosuppressant ineffective, so the body rejects the organ.
In this surgery, doctors try to transplant stem cells from the bone marrow of the organ donor to the recipient, along with the kidney.
So far, none of the three patients had the disease graft-versus-host (GvHD) severe and they also don’t need medicine immunosuppressant in the long run.
“This is a breakthrough,” said Amit Tevar, chief surgeon of the Kidney and Pancreatic Transplant Program at the University of Pittsburgh Medical Center.
The three kidney transplant recipients are Krus Davenport (8), Paizlee (7), and one other child, they suffer from a rare immune disease called Schimke immuno-osseous dysplasia (SIOD).
Their rare condition causes chronic kidney disease and bone marrow failure. So they need a kidney transplant as well as stem cells.
The donors of the three children are their respective parents.
First, doctors complete the stem cell transplant. Then, five to 10 months later after the child recovers, the doctor transplants a kidney.
All three patients have now been living with their new, fully functioning kidneys for 22 to 34 months.
“They go through it all, go to school, go on vacation, they exercise. They lead completely normal lives,” said lead author of the report and professor of pediatrics at Stanford, Alice Bertania.
The surgical technique, named DISOT for multiple or solid immune organ transplantation, received US Food and Drug Administration (FDA) approval on May 27 to treat patients with certain conditions, which affect the kidneys.
Source: suara.com
–
