The fruit that fights colon cancer. The researchers investigated the effects of a metabolite called urolithin A on colorectal cancer. Urolithin A is the result of gut bacteria metabolizing a type of polyphenol found in pomegranates. They found that in tests on mice, the metabolite limited tumor growth and acted synergistically with immunotherapy. The researchers noted that further research is needed to better understand the underlying mechanisms and to see if the findings can be replicated in humans. Colorectal Cancer it is the third most frequently diagnosed cancer globally. A patient’s chances of survival can be predicted by the immunoscore, which is calculated from the density of cells that induce tumor death (CD8+ cells). Recent studies show that concentrated forms of urolithin A (UA), a natural product resulting from the digestion of pomegranate, induce mitophagy – degradation of old or useless cells known as mitochondria. In turn, this encourages the creation of new mitochondria and slows the progression of age-related diseases. Other studies have found that UA has immunomodulatory effects on cells that reduce inflammation as well as cells that improve immune function. Further studies of UA’s effects on function immune system could lead to the development of antitumor treatments.Recently, researchers explored the effects of UA on colorectal cancer in mice. They found that UA induced the formation of powerful anti-tumor T cells in mice both when they consumed pomegranates and when they were used in conjunction with CAR-T cell therapy, a treatment in which T cells – a type of immune cell – are modified to attack cancer cells. “Our findings are particularly interesting because the focus is not on the tumor cell, but on the immune system, the natural defense against cancer,” said Dr. Dominic Denk, a physician at University Hospital in Frankfurt, Germany, and first author of the current study. .“This is where reliable therapeutic approaches are still lacking in the reality of colorectal cancer patients. By potentially improving the therapy in combination with existing immunotherapies, the study opens up significant possibilities for further application in clinical trials. We hope to use this to sustainably improve the therapy of colorectal cancer as well as other types of cancer,” he added. The study appeared in Immunity.UA is a metabolite of ellagitannins, a type of polyphenol. Polyphenols are known to have antioxidant and anti-inflammatory properties. Ellagitannins are mainly found in pomegranates, but also in strawberries, raspberries and walnuts. In addition, these foods contain a multitude of nutrients and bioactive substances that are generally beneficial for overall health. That being said, ellagitannins are converted into UA by gut bacteria. Thus, you must have an intact and diverse intestinal microbiome to allow this conversion, writes doctorulzilei.ro.
2024-02-24 23:08:56
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