March 23, 2020 11:55
Cells promote the growth of nerves, including cancer cells. According to a media release, researchers from the University of Zurich (UHZ) have now proven this in two studies. Intervening in this communication between stem cells and neurons creates new opportunities for the artificial regeneration of tissue and for cancer treatment.
In the first work, the research team headed by Thimios Mitsiadis, professor at the Institute for Oral Biology at UHZ, compared the interaction of neurons with two different types of stem cells in the tooth and bone marrow. Both can mature into different cell types such as bone, cartilage and fat cells. They use the “organ-on-a-chip” technology, small 3-D biochips that simulate the basic functions of human organs and tissues. They found that, in addition to bone marrow cells, dental stem cells are also a promising option for the regeneration of functional facial tissue that is correctly equipped with nerves.
In the second study, the team examined the interaction between nerves and cancer stem cells found in aggressive oral cancer ameloblastoma. These cancer cells also attracted nerves and made contact with them. “It seems that nerves are fundamental to the survival and functioning of cancer stem cells,” explains co-author and junior group leader Pierfrancesco Pagella.
Mitsiadis summarizes the value of these research results: “Our results create new opportunities for cancer treatment with drugs that interfere with the communication between nerve cells and cancer stem cells.” Mm
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