More commonly called statins (HMG-CR) are the inhibitors used to fight high cholesterol and some cardiovascular diseases. They work by reducing the concentration of total cholesterol (LDL and HDL) and triglycerides in the blood. Furthermore, it will surprise us to know that this common drug is derived from a fungus. In fact, the first statin was discovered in the 1970s in the Akira Endo mushroom.
Today the statins used are synthetic and can have different characteristics. They all work in the liver, where they metabolize cholesterol. Some, such as pitavastatin, are very potent and have the effect of significantly lowering cholesterol levels. Over time, in fact, these inhibitors have demonstrated their validity in the treatment of the aforementioned pathologies. The use of statins has greatly reduced mortality from hypercholesterolemia and they are used as a preventative drug. Unfortunately, however, muscle aches and other side effects of statins against cholesterol and cardiovascular problems are associated with the treatment. Therefore, the administration of statins may have different reactions depending on the patient.
Muscle aches and other side effects of statins against cholesterol and cardiovascular problems
To date, there are many studies that highlight an important link between statin administration and the risk of renal, hepatic dysfunction and muscle pain. As for muscle pain, we talk about statin myotoxicity. It presents with fatigue, tiredness, muscle aches and cramps and tendon pain. According to studies the high dosage is affecting the toxicity of statins. A 2007 study in the UK found that high doses of statins increase the risk of muscle pain by six times. Clearly these parameters vary from subject to subject.
According to some studies, statins can also be toxic to the liver. We speak of hepatotoxicity when the drug inhibits the organ with the risk of injury and dysfunction. In particular, this possibility seems to increase in elderly patients who suffer from multiple pathologies. Episodes of liver injury related to statin administration also occur in organ transplant recipients who are seropositive and immunosuppressed.
A lot of attention is also paid to the interaction between statins and other drugs. The mix of these would increase the risk of side effects, most frequently muscle cramps and liver pain. Clearly all these symptoms should not lead to abandonment of therapy. With the help of your doctor it is possible to evaluate the most suitable administration. Scientific studies, in this sense, continue to work in search of safe answers.
Deepening
A cereal against heart attacks and cholesterol but beware of contraindications
