Low-Cost Oral Vaccine for Broiler Chickens to Fight Campylobacteriosis: A Sustainable Solution

A oral vaccinelow-cost and sustainable, which would be supplied to broiler chickens for
fight the
campilobacteriosisa disease that causes chronic diarrhea caused by bacteria
campylobacter, which is resistant to antibiotics. It is the objective of a research that is being carried out in Argentina to combat a food-borne pathology that affects health due to the handling and consumption of this contaminated animal.

Uriel Miralles He is a student of the Bachelor’s Degree in Biotechnology at the Faculty of Chemistry, Biochemistry and Pharmacy (FQByF). Next to Jeremiah Conradomechatronic from the regional UTN Córdoba, promote BioSpi, an initiative that aspires to be a company dedicated to biotechnology with an innovative focus on sustainable biological therapies. Both have proposed solving a zoonosis problem with the development of an oral vaccine for farm chickens.

The meat of this bird is a food implicated in food infections caused by the campylobacter bacteria. “When there are many animals in intensive farming, a proliferation of diseases is generated that are then transmitted to humans, and that is when the problem arises (…) We can take as an example what was influenza A in 2009 and part of Covid- 19 recently,” he explained.

Miralles maintained that currently to resolve similar situations, antibacterials are used that have been overcome by the bacteria themselves, generating a resistance mechanism. “This resistance generates a circle that endangers people’s health (…) Our objective is to attack the problem from the root, that is, immunizing the animal against the bacteria (…) The purpose is to combat the disease campylobacteriosis,” he explained.

Spirulina
The spirulina It is a microalgae capable of producing biomolecules. This means that it has the ability to synthesize specific molecules against various pathogens. “With the help of synthetic biology we aim to enhance this special characteristic and make spirulina personalized to attack this disease.”

The oral vaccine would be in the form of a pill, created with biologically synthesized microalgae with molecules that would directly attack the bacteria that triggers the infection.
campilobacteriosis. “We are in the initial course of development that involves computational modeling (…) In the coming months, we are going to focus on the validation of the technology as such,” said Uriel.

One of the advantages of this technology is that, just as an antigen could be carried against campylobacterbeing from
delivery an antigen could be carried against
Salmonella or other bacteria that trigger different infectious diseases that come from intensive animal husbandry. “In the future we could offer this vaccine to treat other bacteria in other animals such as cows and pigs,” he concluded.

2023-11-20 20:56:18
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