Israeli Researchers Grow Laboratory Testicles to Address Male Infertility
In a groundbreaking development, researchers at Bar-Ilan University in Israel have successfully grown “laboratory testicles” that could potentially revolutionize the treatment of male infertility. Male infertility affects approximately 10% to 15% of American men, and this innovative approach aims to provide a solution to this widespread issue.
Led by Dr. Nitzan Gonen, the team of researchers utilized cells extracted from mouse testes to create tiny artificial organs that closely resemble the structure and function of natural mouse testicles. The ultimate goal is to develop human-like testicles from human stem cells, which could be used to treat developmental sex disorders and infertility in humans.
While fertility clinics can identify some of the problems that cause male infertility, such as low sperm count or abnormal structure, the underlying causes remain largely unknown. Dr. Gonen explains, “We don’t understand fully what causes this, which genome mutations led to the condition, or what went wrong in the testicle’s functioning.” However, with the laboratory testicles they have created, researchers will now be able to study these subjects within a controlled system.
This groundbreaking achievement builds upon previous advancements in the field of stem cell research. Biologists have already successfully generated organoids, miniature versions of immature organs, including the brain, kidneys, and intestines, from stem cells. Dr. Gonen’s team took this concept a step further by culturing organoids from immature testicular cells extracted from neonatal mice.
After 14 days of incubation, the researchers observed tubular structures resembling in vivo testis. These artificial mouse testicles functioned well for a period of nine weeks, which is sufficient time for mouse sperm generation and release. Testicles play a crucial role in sperm production and maturation, as well as the synthesis of testosterone, the primary male sex hormone.
The study findings, recently published in the International Journal of Biological Sciences, highlight that the organoids showed “signs of entry into meiosis,” the process that reduces the number of chromosomes to form sperm cells. This indicates the potential for these laboratory testicles to contribute to the development of functional sperm.
Dr. Gonen envisions a range of applications for this technology. One of the most promising possibilities is helping boys with cancer who may face infertility due to their treatment. By taking biopsies before commencing treatment, fertile sperm can be grown in vitro and frozen for future use in fathering children.
Additionally, Dr. Gonen sees potential in utilizing this technology in the livestock industry. By controlling the sex of farm animals, it would be possible to improve production twofold. This would result in a higher number of desired offspring, reducing the need for culling animals that do not meet the industry’s requirements.
The successful growth of laboratory testicles represents a significant milestone in the field of reproductive medicine. With further research and development, this technology could offer hope to millions of men struggling with infertility worldwide. The potential applications extend beyond human health, with implications for improving livestock production and animal welfare. As science continues to push boundaries, the future looks promising for addressing male infertility and revolutionizing reproductive technologies.
