Impact of calorie intake on aging
When people increase the number of calories they eat 25 percent limit, this slows down theirs aging processwhich is also associated with a significant reduction in the risk of a premature death to up to 15 percent seems to be connected.
In a new study involving experts from Pennsylvania State University (PSU) investigated how calorie restriction affects the biological aging process in healthy adults. The results are published in the English-language journal “Nature Aging“ published.
Study with 220 participants
The team initially shared 220 participants randomly in two groups a. One group ate a normal diet, while the other group ate a 25 percent calorie restricted diet.
How was biological aging measured?
The Researchers analyzed blood samples of the participants to their biological aging to determine. These blood samples were taken before the intervention, after a follow-up period of twelve months and again after a follow-up period of 24 months.
The professionals took advantage Biomarkerto that Tempo and the progress of biological aging determine the duration of the study. For this purpose, an analysis of methylation marks on DNA, which was obtained from white blood cells, took place.
Such DNA methylation marks regulate the expression of genes and are known to be reduced during the aging process, according to the team subject to change.
Three epigenetic clocks studied
Initially, the researchers focused their analysis on three measurements of DNA methylation data, which are also known as epigenetic clocks be designated. Such epigenetic clocks are molecular markers that are used as indicators of the aging process of a cell or tissue.
Epigenetic clocks can help to understand the aging processby showing how epigenetic changes behave over time and how they are associated with specific diseases of old age.
degree of aging determined
The first two measurements concerned the so-called PhenoAge- and the GrimAge clockwhich are used to estimate the biological age were used. The team said these measurements provided a static measure of how much a person had aged.
speed of aging examined
The third measurement concerned the so-called DunedinPACE. This denotes a measure of assessment by which pace of the aging process or the rate at which biodegradation progresses over time. Therefore, DunedinPACE can be viewed as a kind of speedometer of the aging process.
The professionals noted that the calorie restriction only influence on the DunedinPace the other two epigenetic clocks were unaffected.
„The difference in results suggests that measures of the dynamics of aging such as DunedinPACE are more sensitive to the effects of interventions than measures of static biological age‘ explains the author of the study Dr. Calen Ryan in a press release the Columbia University’s Mailman School of Public Health.
Calorie restriction slows pace of aging
The doctor adds that the current study identified evidence that a Kalorienrestriktion the Alterungstempo in humans slowed down. The results of the study also make it possible to assess what kind of effects, for example, intermittent fasting or a time-limited diet could have.
The calorie restriction in the study was with a slowing down the aging process one two to three percent connected, which according to the researchers in other studies to a ten to 15 percent lesser mortality risk led. These effects on aging are comparable to those of a smoking cessation intervention, the team adds.
What are the long-term effects of calorie restriction?
The participants are under further observation to find out whether the intervention long-term effects on the aging has. The experts report that slower DunedinPACE has already been linked to a lower risk of heart disease, stroke, disability and dementia in other studies.
The team is now investigating the long-term effects of calorie restriction and whether the short-term effects already observed translate into a longer-term reduction in age-related chronic diseases or their risk factors. (as)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, et al.: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE tria; in: Nature Aging (veröffentlicht 09.02.2023), Nature Aging
- Columbia University’s Mailman School of Public Health: Calorie Restriction Slows Pace of Aging in Healthy Adults (veröffentlicht 09.02.2023), Columbia University’s Mailman School of Public Health
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.
