One study revealed that vaccine type, age and mental health are factors strongly associated with antibody level after vaccination. and demonstrates the need to be vaccinated despite being infected.
I studypublished today by the journal ‘BMC Medicine’, reveals that one in three people (36%) have been infected with covid and have not been vaccinated You no longer have detectable antibodies one year after infection.
The seroprevalence study was conducted on 1,076 people aged 43 to 72 in Catalonia before the omicron variant was predominant.
Hybrid immunity (vaccination plus infection) is higher and longer lasting
The work, which also confirms it hybrid immunity (vaccination plus infection) is greater and longer lastingit was co-directed by the Barcelona Institute for Global Health (ISGlobal) and the German Trias i Pujol Institute (IGTP), with the support of the Daniel Bravo Andreu Private Foundation (FPDBA).
In this study, they carried out a second measurement in a population cohort of Catalonia six months after the start of vaccination (the first occurred immediately after the first confinement) to monitor the level and type of antibodies against five viral antigens: the protein The whole Spike (S), the binding domain of the RBD receptor, the S2 fragment, the whole nucleocapsid protein (N) or the N-terminal fragment.
They also used information obtained from a questionnaire and medical records to identify factors that potentially determine the extent and duration of response in unvaccinated, vaccinated or vaccinated and infected people.
How long do the antibodies last if you test positive and are not vaccinated?
In total, they included 1,076 people, aged 43 to 72, in the analysis and found that in 36% of infected but unvaccinated people no longer detected antibodies one year after infection, particularly in people over the age of 60 and smokers.
Furthermore, in people with prior infection, vaccination induced considerably higher levels of antibodies than in those without prior infection, levels strongly associated with the extent of the response during infection.
“Our data underscores the importance of vaccinating people, even if they have previously been infected, and confirms that hybrid immunity is superior and longer lasting. This means that people who have been vaccinated but have not passed the infection would have need a recall before those who have not done so have overcome it “, summarized the researcher Marianna Karachaliou.
Which vaccine generated the most antibodies?
Research revealed that eThe factor most strongly associated with the level of antibodies is the type of vaccine and that Moderna’s Spikevax was the one that generated the most antibodies.
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Furthermore, according to the authors, other factors also seem to play a role: people over the age of 60 or with mental illnesses had lower antibody levels after vaccination.
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