Find a clue to improve forgetfulness and memory loss in rheumatoid arthritis patients

IBS “Cognitive function is restored by inhibiting the Maobi enzyme, a star cell in the brain”


The research team led by Chang-Jun Lee, Director of the Center for Cognitive and Sociality Research at the Institute for Basic Science (IBS) and Professor Sang-Yun Jeong of Bundang CHA Hospital, announced on the 26th that they had found a clue to improve cognitive disorders such as forgetting and memory loss in patients with rheumatoid arthritis.

The research team conducted an animal experiment with interleukin-1beta (IL-1β), an inflammatory substance found throughout the body, which affects astrocytes in the hippocampus in the brain and was confirmed to activate “GABA” , which inhibits neurotransmission.

As a result of the analysis of “synovial cells” isolated from the joint tissues of patients with rheumatoid arthritis, it was also revealed that Maobi, which is known to be mainly expressed in astrocytes, is also present in the synovial cells of the joints and is expressed in proportion to the degree of inflammation.

Find a clue to improve forgetfulness and memory loss in rheumatoid arthritis patients


Thus, when the Maobi inhibitor “KDS2010”, currently in clinical trial phase 1, was administered to an animal model of rheumatoid arthritis, joint inflammation was reduced and cognitive function was restored.

The research team explained that this demonstrates that Maobi in brain stellate cells and joint synovial cells is an effective therapeutic target that can relieve joint inflammation while improving cognitive impairment.

Director Chang-Jun Lee said, “This is the first study to suggest that cognitive impairment in rheumatoid arthritis patients is caused by reactive astrocytes caused by chronic inflammation.

/ yunhap news

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