the molnupiravir is a broad antiviral treatment For example, an acoustic spectrum represents the intensity … “data-url =” https://www.futura-sciences.com/sciences/definitions/physique-spectre-1663/ “data- more = “Read more”>spectre developed by the Merck laboratory, capable of halving deaths and hospitalizations in the context of infection with Covid-19. Son marketing authorization is the subject of a request to the FDA since the beginning of October 2021. Recent studies show that it blocks the replication viral and therefore becomes a candidate for reducing the risk of transmission of Covid-19.
Fooling the virus: the mechanisms of action of molnupiravir
the SARS-CoV-2 is a virus ARN with a very large genome compared to other viruses of this type (Hepatitis C). For its multiplication, the virus needs a enzyme l’RNA polymerase which participates in the synthesis of new The so-called simple covalent bond … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/d/0/e/d0e3dc7e1e_76472_molecule.jpg “data -url = “https://www.futura-sciences.com/sciences/definitions/chimie-molecule-783/” data-more = “Read more”>molecules RNA structure
RNA is a molecule made up of a chain of ribonucleotides (adenine, cytosine, guanine, uracil) linked together … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/ midioriginal / f / 6 / a / f6aa50645c_50034152_arnt-yikrazuul-cc.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/genetique-arn-97/ “data-more =” Read more “>ARN viral. In the case of SARS-CoV-2, the function of RNA polymerases
If RNA polymerase is unique among … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/0/7/9/0795b855fe_50036520_rnapol-abbondanzieri-dp.jpg ” data-url = “https://www.futura-sciences.com/sante/definitions/biologie-arn-polymerase-9016/” data-more = “Read more”>RNA polymerase has evolved into a The speed having a direction and an intensity is represented by a vector, the speed vector. Relative speed is the speed of one body relative to another or relative to a benchmark. “Data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/3/1/ 9 / 319daf63f4_77541_leibniz-dp.jpg “data-url =” https://www.futura-sciences.com/sciences/definitions/physique-vitesse-324/ “data-more =” Read the definition “>speed synthesis 10 times greater than those usually encountered in this type of virus which is accompanied by a loss of precision in the Chez … “data-image =” https://cdn.futura-sciences.com/buildsv6/ images / midioriginal / c / 2/8 / c282d0a8da_115313_arn-polymerase.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/biologie-transcription-271/ “data-more =” Read more “>transcription. It is this peculiarity, described as the Achilles heel of the virus, which induced a new concept of antivirals: to deceive the enzyme by making it synthesize an erroneous genetic code, thereby stopping the multiplication of the virus. virus.
Molnupiravir is a nucleoside analogue whose therapeutic target is the replication of the virus whose structure is very similar to ribonuleoside cytidine normal.
A Active ingredients and drugs
There are active ingredients in some … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/e/c/c/eccc00be33_78221_principe-actifjpg.jpg “data-url = “https://www.futura-sciences.com/sante/definitions/medecine-principe-actif-15081/” data-more = “Read more”>substance active contained in molnupiravir, β-DN-hydroxycytidine (NHC) replaces the cytidine naturally used by RNA polymerase as a building block in RNA synthesis. This substitution generates copy errors that are deleterious to the replication of the virus.
Molnupiravir: advantages and limitations
This oral drug is an attractive candidate for treatment and even prevention of Covid-19 infection. Home use and the effectiveness of its demonstrated action on clinical tests phase III offer interesting perspectives in the treatment of viruses.
However, there are still some controversies regarding the effect mutagenic induced by molnupiravir. Indeed, the antiviral activity is correlated with the level of mutagenesis in the RNA of the virus. From studies have shown that it also exhibits mutational activity for the host, in particular, on cells in division where the synthesis of DNA structure
DNA is a very long molecule, composed of a succession of nucleotides attached to each other by phosphodiester bonds. There are four … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/e/6/5/e65f7c1212_95629_adn-definition.jpg “data-url =” https: / /www.futura-sciences.com/sante/definitions/medecine-adn-87/ “data-more =” Read more “>ADN is in progress. Risks must therefore be carefully assessed when implementing the therapy.
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