Corona viruses spread primarily through the air. When an infected person speaks, coughs, sneezes, or laughs, they excrete virus droplets in their breath. In this way, the pathogens can get into the airways of other people and infect them. A Berlin research team wants to fight the virus exactly where it attacks first: on the mucous membranes of the nose, mouth, throat and lungs. For this purpose, the scientists have developed a nasally administered, attenuated live vaccine against SARS-CoV-2. In the current issue of the journal “Nature Microbiology”, the interdisciplinary team describes how this attenuated live vaccine provides better immunity than vaccines that are injected into the muscle.
Additional information
literature
Geraldine Nouailles et al. (2023): A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants, in: Nature Microbiology, DOI: 10.1038/s41564-023-01352-8
