University of Florida “Possible through activation of the cartilage management protein ‘RORβ (beta)'”
A target has been discovered that can be of great help in the development of new drugs that can fundamentally cure arthritis (osteoarthritis).
The University of Florida’s Scripps Biomedical Research Institute found that activating “specific proteins” in chondrocytes can restore joint flexibility to healthy levels and control inflammation. This specific protein is called “RORβ” and is short for “orphan receptor beta related to the retinoic acid receptor”. It is a type of protein called a nuclear receptor. It is responsible for managing chondrocytes, a type of cell that is important for maintaining the health of the cartilage within the joint.
Professor Patrick Griffin (Biochemistry and Molecular Medicine), lead author of the study, said: “As we age and the joints are stressed, chondrocytes begin to decline. Activation of RORβ can prevent or delay osteoarthritis.” “There is currently no drug to adequately control arthritis, which is considered the number one cause of disability in the United States,” he said. “Although our research is in its infancy, RORβ could provide a new therapeutic target to protect cartilage from damage and activate cartilage regeneration,” he added.
According to the research team, about 32 million Americans suffer from arthritis. Experts say there are ways to reduce the risk of arthritis: low-impact exercise, regular stretching every day, eating foods that reduce inflammation, adequate fluid intake, strict blood sugar control, not smoking or drinking (or not drinking), maintaining a normal weight and immunity Maintenance or improvement ▷ 7-9 hours of sleep per day have been selected.
The results of this study (RORβ modulates a protective genetic program against joint cartilage damage) were published in the journal PLOS One and introduced by MedicalXpress, an American medical and health media.
