Alopecia areata (AA) is an autoimmune disease that causes hair loss. While it has long been known to have an association with other autoimmune diseases such as thyroid disease and vitiligo, a recent study published in the Journal of the American Academy of Dermatology has found a link between AA and inflammatory arthritis.
The study, conducted by Colin M. Kincaid and colleagues from the University of California at Irvine, used medical records from 75 healthcare organizations to determine if an association exists between AA and inflammatory arthritis. The analysis included 46,682 patients with AA and matched controls.
The researchers found that patients with AA had a significantly higher risk for developing psoriatic arthritis (odds ratio [OR], 2.344), rheumatoid arthritis (OR, 2.09), and ankylosing spondylitis (OR, 1.68) versus controls. Individuals with AA and concomitant inflammatory arthritis were mostly female, with the highest proportion having AA with rheumatoid arthritis (84 percent female). AA was also associated with the development of “other crystal arthropathies” (OR, 1.763) and “other inflammatory arthropathies” (OR, 1.631). Rates of gout were similar between the cohorts.
“In this large-scale cohort study, AA patients with inflammatory arthritis were older (average age, 54.4 years old), raising the question of whether we should screen patients with AA for arthritis and at what age,” the authors write.
The researchers suggest that the link between AA and inflammatory arthritis may be due to a shared genetic susceptibility, a common environmental trigger, or both. They also note that the link between AA and inflammatory arthritis may have implications for treatment, as some treatments for AA, such as JAK inhibitors, may also be effective for inflammatory arthritis.
While further research is needed to fully understand the link between AA and inflammatory arthritis, the study highlights the importance of monitoring patients with AA for the development of other autoimmune diseases and the need for timely intervention.
In conclusion, the study provides important insights into the association between AA and inflammatory arthritis, and the potential implications for diagnosis, screening, and treatment. Healthcare providers should be aware of this link and screen patients with AA for the development of other autoimmune diseases. Further research in this area is needed to fully understand the mechanisms underlying this association and to develop more effective treatments for patients with AA and inflammatory arthritis.
