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First person to be cured of HIV dies at age 54 …

Timothy Ray Brown was the first person known to be cured of an HIV infection. On Tuesday, his partner Tim Hoeffgen announced that Brown had died of cancer.

“It is with great sadness that I announce that Timothy has passed away this afternoon,” Hoeffgen wrote on Facebook. “He was surrounded by myself and friends after a five-month battle with leukemia.”

Brown went down in history as “the Berlin patient,” to protect his identity. He was diagnosed with HIV in 1995 in Berlin, where he lived at the time, but he was an American.

In 2007, in addition to HIV, Brown was diagnosed with leukemia, and his doctor suggested a risky treatment. The German doctor Huetter, who treated Brown, decided to completely destroy his patient’s immune system. Afterwards, stem cells with a CCR5 mutation, which is resistant to HIV, were transplanted.

“I stopped taking my medication the day I got the transplant, after three months there was no more HIV in my body,” he testified to the British BBC in 2012.

This treatment was extremely expensive, risky and complex, not least because very few people have the CCR5 mutation. According to experts, this can never be an effective treatment for other patients, as many would simply risk their lives by undergoing this.

The International AIDS Society said Brown gave the world hope because an HIV cure is indeed possible. According to Peter Staley, a prominent American AIDS activist, he took that responsibility with pleasure. The two became close friends through their shared battle with the disease.

The transplant cured Brown of the leukemia, but the cancer came early this year. The prognosis was poor, he had metastases to the brain and spinal cord. That relapse has now become fatal to him.

In the meantime, a second person has been cured of HIV: Adam Castillejo. He was known as the ‘London patient’ for a long time, until he revealed his identity himself this year. He received treatment similar to Brown and was able to stop taking his HIV medication.

Worldwide, more than 37 million people are infected with the HIV virus. The AIDS pandemic has claimed more than 35 million lives since it broke out in the 1980s.

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So very sad. Timothy Ray Brown, the first person cured from AIDS, known as The Berlin Patient, died yesterday from cancer. The chance he took with his docs in Berlin helped reignite AIDS cure research. He became our proof-of-concept. And wonderfully, he became our friend. Frightened to go before the press after some brain damage from the bone marrow transplant he went through, Tim ended up doing dozens of pitch-perfect interviews, and then joined the international club of AIDS activists, attending all the international AIDS conferences, hugging us, dancing with us at the off-site parties, and obviously loving that he had found our beautiful family. His partner Tim Hoeffgen was often by his side (on the right in this pic) Timothy became our smiling example of hope for a cure. A heavy responsibility which he never shied away from. He was a rascal too. I bumped into him in the back rooms of the no-pants party in Amsterdam two years ago, and laughed with joy when he told me he was on PrEP. “It wouldn’t be cool if the only guy cured from AIDS got it a second time,” he said, with a huge smile. When the cure finally comes, let’s all have a communal toast to this amazing man. ?? from #USCA2015 in Washington DC

A message shared by Peter Staley (@staleypr) on 30 Sep 2020 at 5:35 (PDT)


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