Here’s a breakdown of the provided text, focusing on the key information about the LiTA-HM technology:
What is Neurovascular Coupling (NVC)?
NVC is the process where increased neural activity leads to the dilation of nearby blood vessels.
This dilation increases blood supply to meet the higher energy demands of active neurons. NVC is crucial for normal brain function and for non-invasive brain-computer interfaces (BCIs).
The Problem with Existing Technologies:
Conventional technologies have limitations in their detection range and/or spatiotemporal resolution.
This prevents precise analysis of dynamic changes in neurons and blood vessels across the entire cortex.
these limitations hinder research into the full potential of NVC.
The Solution: The lita-HM (Linear Transducer-Array-Based Hybrid Microscope)
Developed by: A research team from the Shenzhen institute of Advanced Technology of the Chinese Academy of Sciences, led by Profs. ZHENG Hairong,LIU Chengbo,and ZHENG Wei. Published in: Science Advances on July 23.
What it does: Enables simultaneous, dynamic, high-resolution imaging of neuronal activity and microvascular behavior across the entire cortex of awake mice.
Key Technical Innovations of LiTA-HM:
- high-Speed Polygon Scanning System:
For optical-resolution photoacoustic microscopy.
Significantly increases imaging speed.
Maintains system stability.
- Optimized Optical Pathways:
Provide uniform 6-μm resolution.
Cover a 6.5-mm range.
Feature a flat imaging plane.
These elements are foundational for high-resolution, rapid multimodal imaging.
- 8-Channel Transducer Array:
Expands the imaging field of view.
Has a 6-mm detection range.
Maintains high sensitivity.
Allows the polygon scanner to operate in air,eliminating interference from coupling media without sacrificing speed or stability.
- Novel Image Reconstruction Algorithm:
Uses weighted averaging and adaptive stripe filtering.
Effectively suppresses transducer-induced artifacts.
Significantly improves the signal-to-noise ratio.LiTA-HM’s Capabilities:
High-speed, large-field-of-view visualization: Of neurovascular activity in awake mice.
Captures: Capillary-scale vascular networks and single-neuron soma details.
Coverage: Across the entire cortex.
Resolution: 6-μm spatial resolution.
Field of View: 6 mm × 5 mm.
Speed: 1.25 frames per second.
Functionality: Allows real-time, full-cortex monitoring of neurovascular dynamics.Applications and Potential:
Successfully used in awake mouse experiments for brain disease models and functional imaging. Highlights its potential for advancing brain research.
Offers practical applications.
provides a new tool for non-invasive BCI data acquisition.
