here are the key takeaways from the text, focusing on the sisters’ story and the research developments:
Silvia and Elena’s Story:
* Silvia needed a kidney transplant and began dialysis.
* Elena, Silvia’s sister, volunteered to donate a kidney. Initially hesitant due to her children, she was inspired by their mother’s experience with a kidney removal and long life afterward.
* The donation process was rigorous, involving extensive medical and psychological evaluations to ensure it was a genuine and informed decision.
* Both sisters feel positively impacted by the transplant. Elena describes it as “giving birth to another child,” and Silvia acknowledges the immense strength of the gesture.
* Both sisters are now living normal lives and actively involved in volunteer work.
Research Developments (Mario Negri Institute):
* Silvia participated in a Mario Negri trial aimed at eliminating the need for anti-rejection therapy. She received mesenchymal cells before the transplant and has as been able to completely eliminate immunosuppressants as of January of the current year.
* The initial results of the trial were promising.
* Ongoing and future research:
* A new study called “Phoenix” is underway with international collaboration (Canada, Spain, France).
* A potential “cell farm” for transplants is being considered at Kilometro Rosso in Bergamo.
* An Irish organization is seeking EU funding for related research.
* A new transplant Immunology Laboratory will open at Kilometro Rosso in 2026, building on 15 years of experience.
* Strong collaboration between Mario Negri and Pope John XXIII Hospital on transplant research, kidney diseases, diabetes, rare and neurological diseases.
* The institute receives many requests for treatment highlighting the need for continued investment in research.
The text emphasizes the power of organ donation, the importance of research in improving transplant outcomes (specifically reducing or eliminating the need for immunosuppressants), and the collaborative spirit driving advancements in the field.
