On September 18, 2025, the U.S. government (USG) unveiled its new America First Global Health Strategy, marking a significant shift in how the United States approaches international health cooperation. this strategy centers on forging bilateral health cooperation agreements – Memorandums of Understanding (MOUs) – with countries receiving U.S. global health assistance. These MOUs, spanning five years (2026-2030), aren’t simply aid packages; they’re strategic partnerships designed to foster self-reliance and durable health systems in partner nations. A core tenet of this new approach is a commitment from partner countries to increase their own domestic health spending, effectively “co-investing” in their health infrastructure as U.S. assistance gradually decreases. The U.S. began signing these agreements in late 2025, and implementation is underway.
Understanding the New US Global Health Strategy
The “America First” strategy represents a departure from previous models of global health engagement. Historically,U.S. global health assistance often involved direct funding of programs and initiatives.While this approach yielded critically important results, it sometimes created dependency and didn’t always lead to sustainable improvements in health systems. The new strategy aims to address these shortcomings by prioritizing country ownership and long-term capacity building. This isn’t about disengaging from global health; it’s about changing how the U.S. engages.
Key Principles of the MOUs
- Country Ownership: Partner countries are expected to take the lead in identifying their health priorities and developing strategies to achieve them.
- Co-Investment: A commitment to increasing domestic health spending demonstrates a partner country’s dedication to long-term health security.
- Transition to Self-Reliance: The gradual reduction of U.S. assistance is intended to incentivize countries to build sustainable health systems that aren’t reliant on external funding.
- Strategic Alignment: MOUs are designed to align with both U.S. and partner country priorities, ensuring that resources are used effectively.
- Five-Year Planning Horizon: The five-year timeframe provides a structured approach to planning, implementation, and evaluation.
Tracking the bilateral Health Agreements
This tracker provides a current overview of the MOUs signed to date. it’s critically important to note that detailed details contained within the MOUs – specific program areas, financial allocations, and data-sharing agreements – isn’t yet publicly available. The data presented here is based on official press releases issued by the U.S. Department of State. This tracker will be continuously updated as new agreements are signed and more comprehensive data becomes accessible.
Analyzing the Data: Initial Trends
Early data reveals several key trends. Firstly,the level of co-financing pledged by partner countries varies substantially. This suggests differing levels of economic capacity and political commitment to health investment. Secondly, program areas targeted by the MOUs are diverse, reflecting the unique health challenges faced by each country.However, a consistent focus on global health security (GHS) – including pandemic preparedness and response – is evident across many agreements. This underscores the U.S.’s commitment to strengthening global defenses against infectious disease threats, a lesson learned from the COVID-19 pandemic.
The shift in funding models is also apparent. While historical U.S. global health funding has been considerable, the proposed five-year funding under the MOUs indicates a planned reduction in direct U.S. assistance, coupled with an expectation of increased domestic investment from partner countries. this transition requires careful monitoring to ensure that it doesn’t compromise essential health services in the short term.
Methodology and Data Limitations
This tracker relies on publicly available information from U.S.Department of state press releases. The categorization of program areas is based on keyword searches within these releases.Specifically, agreements are classified as focusing on Global Health Security (GHS) if they explicitly mention GHS or include descriptions of activities related to outbreak preparedness and response. It’s crucial to acknowledge that this methodology has limitations. Press releases provide a high-level overview and may not capture the full scope of program areas targeted in each MOU. Furthermore, the absence of detailed MOU documents prevents a more granular analysis of specific interventions and financial allocations.
As more information becomes available – including the release of the full MOU texts – this tracker will be updated to provide a more comprehensive and accurate picture of the U.S.’s new approach to global health cooperation.
Looking Ahead
the “America First” Global Health Strategy and the associated bilateral MOUs represent a significant evolution in U.S. global health policy. The success of this new approach will depend on several factors, including the willingness of partner countries to fulfill their co-investment commitments, the effectiveness of U.S. technical assistance in supporting capacity building, and the transparency and accountability of program implementation. Ongoing monitoring and evaluation will be essential to assess the impact of these MOUs on health outcomes and to identify areas for advancement. The coming years will be critical in determining weather this new strategy can achieve its enterprising goals of fostering sustainable, resilient, and country-led health systems around the world.
Frequently Asked Questions (FAQ)
- what is the purpose of the MOUs? The MOUs are designed to transition U.S. global health assistance towards a more sustainable model of country ownership and co-investment.
- How long do the MOUs last? Each MOU covers a five-year period (2026-2030).
- What is “co-investment”? Co-investment refers to the commitment from partner countries to increase their own domestic health spending as U.S. assistance decreases.
- Where can I find the full text of the MOUs? Currently, the full texts of the mous are not publicly available. Information is based on U.S. Department of State press releases.
- How will the success of the MOUs be measured? Success will be measured by improvements in health outcomes, the sustainability of health systems, and the degree to which partner countries are able to finance their own health programs.
Key Takeaways
- The U.S. is shifting its global health strategy towards bilateral agreements focused on country ownership and co-investment.
- The MOUs represent five-year plans (2026-2030) for U.S. engagement in partner countries’ health efforts.
- A key component of the strategy is a commitment from partner countries to increase their domestic health spending.
- Data on the mous is currently limited to information released in U.S. Department of State press releases.
- The success of the strategy will depend on effective implementation, monitoring, and evaluation.




