Home » Health » Serotonin activates dermal papilla cells and promotes hair growth

Serotonin activates dermal papilla cells and promotes hair growth

  • Oh, J. W. et al. A guide to studying human hair follicle cycling in vivo. J. Invest. Dermatol. 136, 34–44. https://doi.org/10.1038/JID.2015.354 (2016).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Legué, E. & Nicolas, J. F. Hair follicle renewal: Organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development 132, 4143–4154. https://doi.org/10.1242/dev.01975 (2005).

    Article
    CAS
    PubMed

    Google Scholar

  • Saceda-Corralo, D. et al. Association of inflammation with progression of hair loss in women with frontal fibrosing alopecia. JAMA Dermatol. 156, 700–702. https://doi.org/10.1001/jamadermatol.2020.0359 (2020).

    Article
    PubMed
    PubMed Central

    Google Scholar

  • Hasan, R. et al. Effects of hormones and endocrine disorders on hair growth. Cureus 14, e32726. https://doi.org/10.7759/cureus.32726 (2022).

    Article
    PubMed
    PubMed Central

    Google Scholar

  • Arck, P. C. et al. Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am. J. Pathol. 162, 803–814. https://doi.org/10.1016/S0002-9440(10)63877-1 (2003).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Hughes, E. C., Syed, H. A. & Saleh, D. Telogen Effluviumin. StatPearls. https://pubmed.ncbi.nlm.nih.gov/28613598/ (2025).

  • Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P. & Tosti, A. The role of vitamins and minerals in hair loss: A review. Dermatol. Ther. (Heidelb) 9, 51–70. https://doi.org/10.1007/s13555-018-0278-6 (2019).

    Article
    PubMed

    Google Scholar

  • Mahmud, M. R. et al. Impact of gut microbiome on skin health: Gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes 14, 2096995. https://doi.org/10.1080/19490976.2022.2096995 (2022).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Mock, D. M. Skin manifestations of biotin deficiency. Semin. Dermatol. 10, 296–302 (1991).

    CAS
    PubMed

    Google Scholar

  • Hayashi, A. et al. Intestinal dysbiosis and biotin deprivation induce alopecia through overgrowth of Lactobacillus murinus in mice. Cell Rep. 20, 1513–1524. https://doi.org/10.1016/j.celrep.2017.07.057 (2017).

    Article
    CAS
    PubMed

    Google Scholar

  • Brotzu, G. et al. A liposome-based formulation containing equol, dihomo-gamma-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation. Dermatol. Ther. 32, e12778. https://doi.org/10.1111/dth.12778 (2019).

    Article
    PubMed

    Google Scholar

  • Soh Iwashita, H. M., Ueno, T., Hamamoto, K., Uchiyama, S. & Ueki, R. Equol status affects hair aging in postmenopausal women: A cross-sectional study. J. Jpn. Soc. Aesthetic Dermatol. 30, 8–17 (2020).

    Google Scholar

  • Nam, W. et al. Lactobacillus paracasei HY7015 promotes hair growth in a telogenic mouse model. J. Med. Food 24, 741–748. https://doi.org/10.1089/jmf.2020.4860 (2021).

    Article
    CAS
    PubMed

    Google Scholar

  • Hornung, J. P. The human raphe nuclei and the serotonergic system. J. Chem. Neuroanat. 26, 331–343. https://doi.org/10.1016/j.jchemneu.2003.10.002 (2003).

    Article
    CAS
    PubMed

    Google Scholar

  • Raghupathi, R. et al. Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells. J. Physiol. 591, 5959–5975. https://doi.org/10.1113/jphysiol.2013.259796 (2013).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Liu, N. et al. The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine. Int. J. Mol. Sci. 22, 7931. https://doi.org/10.3390/ijms22157931 (2021).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Layunta, E. et al. Intestinal serotonergic system is modulated by toll-like receptor 9. J. Physiol. Biochem. 78, 689–701. https://doi.org/10.1007/s13105-022-00897-2 (2022).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Karmakar, S. & Lal, G. Role of serotonin receptor signaling in cancer cells and anti-tumor immunity. Theranostics 11, 5296–5312. https://doi.org/10.7150/thno.55986 (2021).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Bamalan, O. A., Moore, M. J. & Al Khalili, Y. Physiology, Serotoninin. StatPearls. https://pubmed.ncbi.nlm.nih.gov/31424752/ (2025).

  • Wu, H. L. et al. 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress. PLoS ONE 9, e89663. https://doi.org/10.1371/journal.pone.0089663 (2014).

    Article
    ADS
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Amireault, P. & Dubé, F. Intracellular cAMP and calcium signaling by serotonin in mouse cumulus-oocyte complexes. Mol. Pharmacol. 68, 1678–1687. https://doi.org/10.1124/mol.104.010124 (2005).

    Article
    CAS
    PubMed

    Google Scholar

  • Kageyama, T. et al. Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction. Sci. Adv. 8, eadd4603. https://doi.org/10.1126/sciadv.add4603 (2022).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kageyama, T., Miyata, H., Seo, J., Nanmo, A. & Fukuda, J. In vitro hair follicle growth model for drug testing. Sci. Rep. 13, 4847. https://doi.org/10.1038/s41598-023-31842-y (2023).

    Article
    ADS
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kageyama, T., Seo, J., Yan, L. & Fukuda, J. Effects of oxytocin on the hair growth ability of dermal papilla cells. Sci. Rep. 13, 15587. https://doi.org/10.1038/s41598-023-40521-x (2023).

    Article
    ADS
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kageyama, T., Seo, J., Yan, L. & Fukuda, J. Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation. Sci. Rep. 14, 4709. https://doi.org/10.1038/s41598-024-55377-y (2024).

    Article
    ADS
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kageyama, T., Seo, J., Yan, L. & Fukuda, J. Effects of oxytocin receptor agonists on hair growth promotion. Sci. Rep. 14, 23935. https://doi.org/10.1038/s41598-024-74962-9 (2024).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Moskowitz, M. A. & Cutrer, F. M. Sumatriptan: A receptor-targeted treatment for migraine. Annu. Rev. Med. 44, 145–154. https://doi.org/10.1146/annurev.me.44.020193.001045 (1993).

    Article
    CAS
    PubMed

    Google Scholar

  • Langan, E. A., Philpott, M. P., Kloepper, J. E. & Paus, R. Human hair follicle organ culture: Theory, application and perspectives. Exp. Dermatol. 24, 903–911. https://doi.org/10.1111/exd.12836 (2015).

    Article
    PubMed

    Google Scholar

  • Agramunt, J. et al. Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons. Sci. Adv. 9, eadh3273. https://doi.org/10.1126/sciadv.adh3273 (2023).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Grymowicz, M. et al. Hormonal effects on hair follicles. Int. J. Mol. Sci. 21, 5342. https://doi.org/10.3390/ijms21155342 (2020).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Nestor, M. S., Ablon, G., Gade, A., Han, H. & Fischer, D. L. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J. Cosmet. Dermatol. 20, 3759–3781. https://doi.org/10.1111/jocd.14537 (2021).

    Article
    PubMed
    PubMed Central

    Google Scholar

  • Choi, S. et al. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence. Nature 592, 428–432. https://doi.org/10.1038/s41586-021-03417-2 (2021).

    Article
    ADS
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Niu, Y. L. et al. Melatonin promotes hair regeneration by modulating the Wnt/beta-catenin signalling pathway. Cell Prolif. 57, e13656. https://doi.org/10.1111/cpr.13656 (2024).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kang, W., Park, S., Choi, D., Son, B. & Park, T. Activation of cAMP signaling in response to alpha-phellandrene promotes vascular endothelial growth factor levels and proliferation in human dermal papilla cells. Int. J. Mol. Sci. 23, 8959. https://doi.org/10.3390/ijms23168959 (2022).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Lee, C. Y. et al. Hair growth is promoted by BeauTop via expression of EGF and FGF-7. Mol. Med. Rep. 17, 8047–8052. https://doi.org/10.3892/mmr.2018.8917 (2018).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Pejcic, A. V. & Paudel, V. Alopecia associated with the use of selective serotonin reuptake inhibitors: Systematic review. Psychiatry Res. 313, 114620. https://doi.org/10.1016/j.psychres.2022.114620 (2022).

    Article
    CAS
    PubMed

    Google Scholar

  • Krasowska, D., Szymanek, M., Schwartz, R. A. & Myśliński, W. Cutaneous effects of the most commonly used antidepressant medication, the selective serotonin reuptake inhibitors. J. Am. Acad. Dermatol. 56, 848–853. https://doi.org/10.1016/j.jaad.2006.10.020 (2007).

    Article
    PubMed

    Google Scholar

  • McCorvy, J. D. & Roth, B. L. Structure and function of serotonin G protein-coupled receptors. Pharmacol. Ther. 150, 129–142. https://doi.org/10.1016/j.pharmthera.2015.01.009 (2015).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kazunori Sasaki, A. K. O. & Isoda, H. Hair Growth-Promoting effect of the coffee bean residue extract on hair follicle dermal papilla cells via the activation of autophagy. J. Funct. Foods. https://doi.org/10.1016/j.jff.2024.106251 (2024).

    Article

    Google Scholar

  • Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27–30. https://doi.org/10.1093/nar/28.1.27 (2000).

    Article
    CAS
    PubMed
    PubMed Central

    Google Scholar

  • Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587–D592. https://doi.org/10.1093/nar/gkac963 (2023).

    Article
    CAS
    PubMed

    Google Scholar

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