World’s Oldest Spanish Woman, 117, Reveals Clues to Longevity in Post-Mortem Study
Madrid, Spain – A complete genetic and lifestyle analysis of María Branas Morera, teh world’s oldest Spanish woman who passed away at age 117, offers new insights into the complex interplay of genetics and lifestyle in achieving extreme longevity. The study, conducted by the Institute of Joseph Carreras in Spain, analyzed blood, saliva, urine, and fecal samples provided by Branas a year before her death, revealing a unique biological profile.
Born in San Francisco, USA in 1907, Branas moved to catalonia, Spain in 1915 and lived through two World Wars, the Spanish Civil War, and the COVID-19 pandemic – even recovering from a bout of the virus at age 113.Researchers found indicators of advanced biological aging, including substantially shortened telomeres, associated with inflammation and leukemia risk. However,they theorize this telomere shortening may have paradoxically reduced her cancer risk by limiting cell division.
DNA analysis revealed protective genes safeguarding heart and brain cells against disease and dementia, alongside low systemic inflammation contributing to a reduced risk of cancer and diabetes. Branas also exhibited efficient cholesterol and fat metabolism. Lifestyle factors also played a crucial role; she never smoked or drank excessively and maintained a healthy weight. Notably,she consumed yogurt three times daily,rich in Bifidobacterium,a beneficial gut microbe.
Despite living alone since 2001, Branas remained socially active within her village and maintained close ties with family. ”Branas’s biological age was 10 to 15 years older than her actual age,” stated Dr. Manel Esteller, who led the study. “She is an example that can open the possibility of drug advancement that mimics the action of good genes.” Dr. Esteller added, “Branas’s parents may have handed out good genes, but we can’t choose our parents.”
The findings suggest longevity isn’t solely steadfast by genetics, but a combination of inherited predispositions and healthy lifestyle choices. this research could pave the way for future therapies aimed at replicating the beneficial effects observed in individuals like Branas, offering potential for extending healthy lifespans.
