Metabolically active visceral fat-the dangerous fat stored deep within the abdomen-has been directly linked to more aggressive forms of endometrial cancer, according to a new study released October 4, 2025. Researchers found a critically important correlation between this type of fat and poorer outcomes for patients diagnosed with the disease,potentially opening new avenues for prevention and treatment.
Endometrial cancer, the most common cancer of the female reproductive system, is projected to affect approximately 66,200 women in the United States alone in 2025, according to the American cancer Society. This discovery is notably crucial because obesity rates continue to climb globally, increasing the number of individuals at risk. Understanding the role of metabolically active visceral fat could lead to targeted interventions-lifestyle changes, medications, or therapies-to mitigate risk and improve survival rates for those diagnosed. The study’s findings suggest a need to re-evaluate current risk assessment strategies and treatment protocols for endometrial cancer, focusing on metabolic health alongside traditional factors.
The research revealed that visceral fat isn’t simply a storage depot; it actively releases hormones and inflammatory substances that can fuel cancer growth and progression. This metabolic activity appears to create a microenvironment conducive to more aggressive tumor behavior, making the cancer harder to treat. Further examination is underway to pinpoint the specific mechanisms driving this connection and to explore potential therapeutic targets.
Citation: Metabolically active visceral fat linked to aggressive endometrial cancer, new study reveals (2025, October 4) retrieved 5 October 2025 from https://medicalxpress.com/news/2025-10-metabolically-visceral-fat-linked-aggressive.html
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