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A Pervasive Bacterial Threat
Helicobacter pylori (H. pylori) stands as a primary instigator of peptic ulcers and the most significant risk factor for the advancement of stomach cancer. The scientific consensus, reflected in numerous U.S. and international guidelines, strongly recommends antibiotic treatment for this infection. Such treatment is proven to prevent ulcer formation and substantially lower the risk of developing stomach cancer.
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Douglas Corley, MD, PhDIn the United States, approximately 30% of the population harbors H. pylori. Globally, this prevalence can surge to between 50% and 70%. When left unaddressed, this bacterium, typically acquired during infancy or early childhood, can lead to persistent inflammation of the stomach lining. This chronic infection considerably elevates the risk of developing stomach cancer. The American Cancer Society projects that in 2025, the U.S. will see an estimated 30,300 new cases of stomach cancer, with H.pylori implicated in roughly 90% of these malignancies.
“Our research offers novel insights into the comparative efficacy of the treatment regimens we currently employ for H. pylori,” stated co-author douglas Corley, MD, PhD, who serves as chief research officer for TPMG and is a research scientist at DOR. “Given Kaiser Permanente’s extensive and diverse patient population, our findings have the potential to guide clinical decision-making for physicians nationwide when managing H. pylori infections.”
This initiative received support from The Permanente Medical Group’s Delivery Science and Applied Research program.Contributing co-authors to this study include Sophie A. Merchant, MPH, and Jessica M. Badalov,MPH,from the Division of research,alongside Shailja C. shah, MD, MPH, affiliated with the University of California, San Diego.
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About the Kaiser Permanente Division of Research
the Kaiser Permanente Division of Research is dedicated to conducting, publishing, and disseminating research in epidemiology and health services. Its overarching goal is to enhance the health and medical care provided to Kaiser Permanente members and the broader community. KPDOR strives to elucidate the factors influencing illness and well-being, while together improving the quality and cost-effectiveness of healthcare delivery. Currently, DOR’s team of over 720 professionals, including 73 research and staff scientists, is actively engaged in nearly 630 research projects focused on epidemiology and health services. For further information,please visit [Insert Website Here] or follow us on twitter at @KPDOR.→ Access the complete original article here.
