Oral Microbiome Implicated in Pancreatic Cancer Risk, new Research Suggests
New York, NY – September 23, 2025 – A groundbreaking study published today in Gut reveals a significant correlation between the composition of oral bacteria and an increased risk of developing pancreatic cancer, one of the deadliest and most arduous-to-treat cancers. Researchers at the New York University (NYU) Grossman School of Medicine found individuals diagnosed with pancreatic cancer exhibited markedly different oral microbiome profiles compared to those without the disease, potentially opening new avenues for early detection and preventative strategies.
Pancreatic cancer is projected to become the fourth leading cause of cancer death in the United States by 2030,according to the Pancreatic Cancer Action Network. Currently, it accounts for approximately 3% of all cancer deaths.The disease often presents with vague symptoms, leading to late-stage diagnoses and poor survival rates.This new research suggests the oral microbiome-the community of microorganisms living in the mouth-could serve as a non-invasive biomarker for identifying individuals at higher risk, potentially enabling earlier intervention and improved outcomes.
The NYU study, involving 361 participants, identified specific bacterial species consistently enriched in the mouths of those with pancreatic cancer. Streptococcus and Veillonella were among the bacteria found in substantially higher abundance.Researchers hypothesize these microbes may contribute to chronic inflammation, triggering a cascade of events that promote tumor development. The study also indicated that the presence of these bacteria preceded cancer diagnosis by as much as two years in some cases.
While the exact mechanisms linking oral bacteria to pancreatic cancer remain under investigation, researchers believe bacterial metabolites entering the bloodstream could play a crucial role. Dr. Jiyoung Kim,lead author of the study and an associate professor of population health at NYU,stated,”Our findings suggest that oral health may be an underappreciated,yet critical,factor in the development of pancreatic cancer.”
Risk Factors and Prevention:
Beyond the newly identified oral microbiome link, established risk factors for pancreatic cancer include:
* Smoking: Smokers are two to three times more likely to develop pancreatic cancer than non-smokers.
* Obesity: Individuals with a body mass index (BMI) of 30 or higher have an increased risk.
* Diabetes: Long-standing diabetes is associated with a higher incidence of the disease.
* Chronic Pancreatitis: inflammation of the pancreas over a prolonged period can elevate risk.
* Family History: Having a family history of pancreatic cancer increases susceptibility.
* Age: The risk increases with age,with most cases diagnosed after age 65.
Preventative Measures:
While pancreatic cancer cannot always be prevented, individuals can take steps to reduce their risk:
* Quit Smoking: eliminating tobacco use is paramount.
* Maintain a Healthy Weight: Achieving and maintaining a healthy BMI thru diet and exercise is crucial.
* manage Diabetes: Effective management of blood sugar levels is essential.
* Limit Alcohol Consumption: Excessive alcohol intake is linked to increased risk.
* Practice Good Oral Hygiene: Regular brushing, flossing, and dental checkups are vital for maintaining a healthy oral microbiome.
* Consider Regular Checkups: Individuals with a family history of pancreatic cancer should discuss screening options with their healthcare provider.
Researchers emphasize that further studies are needed to confirm these findings and determine weather modifying the oral microbiome through interventions like probiotics or targeted oral hygiene practices can reduce pancreatic cancer risk. The next phase of research will focus on larger, longitudinal studies to track changes in the oral microbiome over time and assess the impact of interventions.
