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Ketamine Derivatives: Risks of Overdoses and New Synthetic Drugs

Ketamine Analogues: A Growing Health Risk in France

This article details the increasing dangers associated with ketamine analogues (also known as new synthetic products or NPS) in France. Here’s a breakdown of the key data:

What are Ketamine Analogues?

They are synthetic drugs with chemical structures and effects similar to ketamine, a psychotropic anesthetic used medically.
Ketamine itself is a controlled substance, but these analogues circumvent regulations.
They produce hallucinations, dissociative states (distorted perception of self and surroundings), and in high doses, can cause “K-Hole” (loss of consciousness and feeling of detachment from the body).

Rising Concerns & Risks:

Increased Poisonings: Cases of poisoning related to these substances have significantly increased between 2017 and 2023 (39 reported cases, with 6 resulting in death).
Serious Health consequences: A majority of reported cases (66%) were serious, requiring hospitalization.
Overdose Risk: There’s a high risk of fatal overdose, especially when combined with othre drugs (polyconsumption).
Detection Difficulties: These molecules are frequently enough not detected in standard drug tests, delaying appropriate medical care during emergencies.
Withdrawal Syndrome: Stopping repeated use can lead to anxiety, sleep problems, and potentially severe urinary and liver complications.

Signs of Overdose:

Discomfort
Altered consciousness
abnormal movements (convulsions, agitation)
Delusions of persecution

What to do in Case of Emergency:

Call for help promptly: 112, 15, 18 (or 114 for the hearing impaired).

Resources for Help:

drogues-info-service.fr: Provides information and support for addiction management.
Consult a doctor or addiction specialist.

Challenges in Monitoring:

NPS are constantly evolving, making epidemiological tracking and detection in biological samples difficult for toxicologists.

Source: ANSM (French National Agency for the safety of Medicines and Health Products), French Observatory of Drugs and Addictive Trends, and Lille University Hospital.

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