Dr. Yong answers the question, how many doses of vaccine should be vaccinated? Dealing with the new mutant COVID XBB.1.5

On January 28, 2023, reporters reported that Prof. Yong Phuwarawan, MD, head of the Center of Excellence in Clinical Virology. Department of Pediatrics Faculty of Medicine Chulalongkorn University Post a message that COVID-19 The severity of the disease has always decreased.

COVID-19 has a tendency to decrease in the severity of the disease all the time. with many factors

1. Virus development for survival The virus has evolved to become less virulent. in order to live with human beings Because if it causes violence or death, the virus itself cannot survive. The development of old vaccines such as the polio vaccine, the attenuation of the virus. Will bring the virus because it continues to spread through many times. Over time, the virus will change genetically to weaken. and then used as a vaccine

The same with COVID-19. When infected in humans for a long time, there will be genetic changes to reduce the severity all the time. The global death rate has dropped from 3-5% to about 1% or less than the figure reported by the World Health Organization. But the number of deaths and infections from the World Health Organization found that the number of infections was much lower than reality. So the real mortality rate It will be much less. For Thailand, the death rate has decreased from 1% at first to now less than 0.1%, and even in normal people it should not be different from influenza.

2. Human Infection There are a lot of people who are expected to be more than 70% of the population. Just like in Thailand, we do our studies. It was found that more than 70% of the population has been infected, or about more than 50 million people, and most of the population has received at least 2 doses of vaccine, not less than 80%, resulting in hybrid immunity. which can prevent infection better than vaccine alone or infection alone and proved to reduce the severity of the disease regardless of whether it mutates to XBB.1.5

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3. Vaccines alone cannot prevent infection. At the same time, vaccines induce a higher level of immunity than infection, such as mRNA vaccines, thus exerting greater pressure on the virus to escape the established antibodies for the survival of the virus itself. therefore causing mutations all along In principle, according to evolution when there is pressure The virus tries to avoid it. Therefore, the very high immunity from the vaccine is unable to prevent infection at all. But the immune system in some systems helps to reduce the severity of the disease.

In summary, more than 70% of the infections in our home have been vaccinated and more than 80% of the 2 doses of the vaccine have been given. Therefore, most of the population has hybrid immunity. that can reduce the severity of the disease as well Although the new mutant infection XBB.1.5 that is coming (It is currently the main species in America).

Information from fan page Yong Poovorawan

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