Health Aging processes reversed by new cell therapy

Aging processes reversed by new cell therapy

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Immune cells

by Robert Klatt

© Aging processD. BriggerDBMR, University of Bern

In old age, the immune cell balance of eosinophilic cells and inflammation-promoting macrophages in the adipose tissue gets out of balance. A new eosinophilic cell therapy was able to reverse this process in mice. Clinical trials with humans are expected to follow soon.

Bern (Switzerland). The performance of the Immune system takes with People in old age. This natural one Aging process ensures that seniors are affected by the annual flu wave but also by others Viruses how SARV-CoV-2 be particularly badly affected. In addition to the immunological losses, older people often also suffer from muscle weakness and the resulting lower quality of life.

Scientist of the University of Bern have now introduced a new cell therapy that can reverse the two aging processes. According to the one in the scientific journal Nature Metabolism published study, the therapy is based on the theory that has long been voiced, according to which chronic inflammation in particular triggers diseases typical of old age.

Belly fat causes chronic subliminal inflammation

The team around Dr. Mario Noti and Dr. Alexander Eggel has now proven that these inflammations are mainly caused by visceral fat, i.e. belly fat. In addition, the researchers have shown that eosinophils, these are certain immune cells that are predominantly in the blood but also occur in belly fat, significantly influence aging processes.

Eosinophils belong to the innate immune system. They are responsible for the defense against parasites, but they also regulate inflammatory processes and can trigger respiratory diseases in the event of overreactions. With increasing age, the amount of eosinophilic cells in adipose tissue decreases, in parallel, the amount of inflammatory macrophages increases. This change in immune cell balance leads to Seniors that belly fat becomes a chronic focus of inflammation.

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