FOR IMMEDIATE RELEASE
Author Correction Published: Sirt1‘s Neuroprotective Role in Huntington’s Disease Models Confirmed
A recent correction has been published regarding the article “Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets,” clarifying author affiliations and ensuring accuracy in attribution. The study,originally detailing the neuroprotective effects of Sirt1 activation in Huntington’s disease (HD) models,involved collaborative research across multiple institutions.
Key researchers contributing to the work include Hyunkyung jeong and Dimitri Krainc from Harvard Medical School, Boston, Massachusetts; Tim West and David M Holtzman from Washington University School of Medicine, St. Louis, Missouri; Zhipeng Hou, jiangyang Zhang & Susumu Mori from Johns Hopkins University School of Medicine, Baltimore, Maryland; Huan Cai & Bronwen Martin from the Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging (NIA), US National Institutes of Health (NIH), Baltimore, Maryland; Tamara Seredenina & Ruth Luthi-Carter from the Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; X William Yang from the University of California, Los Angeles, California; Kellie L K Tamashiro & timothy H Moran from Johns Hopkins University School of Medicine, Baltimore, Maryland; Just Susan from the Center for Metabolism and Obesity Research, johns Hopkins University School of Medicine, Baltimore, Maryland; Stuart maudsley & Mark P Mattson from the Laboratory of Neurosciences, NIA, NIH, Baltimore, Maryland; and Christopher A Ross and Wenzhen Duan from Johns Hopkins University School of Medicine, Baltimore, Maryland.
The research highlights the potential of targeting Sirt1, a protein involved in regulating cellular health, as a therapeutic strategy for Huntington’s disease, a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. The study demonstrated that activating Sirt1 in mammalian models led to the activation of multiple downstream targets, resulting in neuroprotection.
