Vitamin B6 Overdose Linked to Nerve Damage Concerns
Australia’s regulator considers limits on high-dose supplements amidst safety worries.
New concerns are emerging about the potential for nerve damage linked to excessive intake of vitamin B6, with Australian regulators considering restrictions on high-dose supplements in response to growing reports of adverse effects.
Vitamin B6: An Essential Nutrient
Vitamin B6, or pyridoxine, is vital for maintaining overall health, playing a key role in the metabolism of proteins, carbohydrates, and fats. Moreover, it facilitates the production of neurotransmitters, which are critical for brain function and mood regulation.
This vitamin also bolsters the immune system by aiding antibody production, essential for fighting off infections. Furthermore, it is necessary for producing hemoglobin, the protein in red blood cells responsible for oxygen transport throughout the body.
While some pregnant women use vitamin B6 supplements to alleviate morning sickness and others take it for premenstrual syndrome, most people get enough B6 from a balanced diet rich in meat, cereals, fruits, and vegetables.
Adults typically need only 1.3–1.7 milligrams daily. Currently, supplements containing 5–200mg of vitamin B6 are widely available, but the Therapeutic Goods Administration (TGA) in Australia is considering limiting sales to pharmacies, requiring consultation with a pharmacist before purchase.
The Risks of Overconsumption
While excess vitamin B6 is usually excreted in urine without causing harm, long-term, high-dose intake is raising concerns. Peripheral neuropathy, or damage to nerves outside the brain and spinal cord, is a primary worry. This condition leads to pain, numbness, and weakness, particularly in the hands and feet.
Although symptoms often subside after discontinuing the supplement, recovery can take months to years for some individuals. Evidence suggests that daily doses exceeding 50mg over extended periods may result in severe side effects. In the United States, the National Institutes of Health (NIH) indicates that vitamin B6 toxicity might occur at doses exceeding 100mg per day (NIH 2024).
Recent data from **Australia** indicates potential underestimation of vitamin B6 supplement side effects. A pathologist running a vitamin B6 testing clinic reported that 4.5% of samples tested in May showed results strongly suggesting nerve damage.
What to Do If You’re Taking Vitamin B6
Current recommendations advise medical monitoring for individuals taking 50mg or more of vitamin B6 daily for over six months. If you regularly take vitamin B6 supplements, discuss ongoing use with a doctor or pharmacist.
Be vigilant for these side effects:
- Numbness or pain in the feet and hands
- Difficulty with balance and coordination due to muscle weakness
- Heartburn and nausea
If you experience concerning side effects after taking vitamin B6 supplements, seek advice from a healthcare professional immediately.
