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Title: Multiple Sclerosis: Gender Differences in Diagnosis and Progression

by Dr. Michael Lee – Health Editor

## Addressing Gender ‍Disparities in Multiple Sclerosis Diagnosis and management

While ⁤biological factors contribute to⁣ differences ‍in Multiple ‍Sclerosis (MS) presentation and progression, disparities in diagnosis and treatment⁤ initiation⁣ significantly​ impact outcomes, ​particularly for men. Research indicates men ‍experience a‍ longer time to report symptoms and seek evaluation for MS compared ⁤to women.5 ​This⁤ delay contributes to‍ a worse prognosis,​ as men may already ⁢have accumulated substantial ​neurological damage by the time of diagnosis.

Several factors may contribute to this diagnostic delay.‍ Men may be less likely to ⁣seek‌ medical attention⁤ promptly due to ​societal expectations surrounding vulnerability and⁣ independence. However, delays aren’t​ solely attributable to patient‍ behavior. Healthcare professionals may also contribute, possibly due to a historical emphasis on MS as a disease primarily affecting‍ women.A shift in perception is⁢ needed, focusing on ‍recognizing neurological symptoms – including⁣ dizziness, numbness, vision⁤ loss, balance problems, and ⁢weakness – regardless⁣ of gender.

Effective MS management for men extends⁢ beyond physical health.Addressing mental wellbeing, including stress and ⁣mood disturbances, and fostering strong ‍social support networks are crucial. These aspects are frequently enough ⁣under-recognized in⁤ men due to societal norms. Encouraging men with MS to prioritize emotional health ⁤and seek support can ‌counteract these stereotypes and improve overall health‌ outcomes.Notably, anxiety and⁤ depression⁢ are common in individuals‍ with MS, affecting over half of those diagnosed, ⁤yet are frequently under-addressed, ⁤especially‍ in men. Studies show newly diagnosed men ‍with MS exhibit higher anxiety⁣ and depression scores, and poorer attention, compared to women.6 This may stem from a reluctance among men to discuss their feelings or a ⁢hesitancy among healthcare providers to initiate these conversations. Vigilance in⁢ recognizing ‌symptoms like fatigue, sleep disturbances, low energy, decreased sex drive, and appetite changes ‌is essential.

Ultimately, early‍ diagnosis and ⁢prompt initiation of disease-modifying therapy are critical for improving outcomes in MS. Recognizing and addressing ⁣the unique challenges ⁢men face in accessing timely diagnosis and ⁤extensive care will significantly impact their prognosis and quality⁣ of life. As ‌in stroke management, time is of the essence in preserving neurological function.

REFERENCES
1.Coyle​ PK. What‍ Can We Learn ⁣from Sex‌ Differences in ⁣MS?. J Pers Med. 2021;11(10):1006. Published 2021 Oct 7. doi:10.3390/jpm11101006
2. Golden LC, ⁤Voskuhl ⁣R. The importance of⁢ studying sex‌ differences in disease: ‌The example of multiple sclerosis. J ⁣Neurosci Res. 2017;95(1-2):633-643. doi:10.1002/jnr.23955
3.Safi ​N.V., Krieger S. Men with Multiple ⁢Sclerosis. Pract. Neurol.2021;February:37-40.
4.Chitnis T. ‍The ‍role of testosterone ⁢in MS risk ‍and​ course.⁣ Mult⁢ Scler. 2018;24(1):36-41. doi:10.1177/1352458517737395
5. Safadi AL, Barry BD, Shin RK. A Cross-sectional Study⁤ of Delayed Diagnosis Associated with Gender and Racial Identity in multiple Sclerosis. J ​Racial Ethn health Disparities. ⁢Published online September⁤ 5, ⁢2025. doi:10.1007/s40615-025-02611-6
6.Prokopova B, Hlavacova N, Vlcek M, et al. Early ⁣cognitive impairment along ‍with decreased stress-induced ‍BDNF in ​male and female patients with newly diagnosed multiple sclerosis.J Neuroimmunol.2017;302:34-40. doi:10.1016/j.jneuroim.2016.11.007

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