Ketogenic Diet Shows Promise for Brain Health, Particularly in Women with Alzheimer’s Risk
A growing body of research suggests a link between diet and brain health, and a new study from the University of Missouri indicates a high-fat, low-carbohydrate ketogenic diet may offer protection against cognitive decline, especially for individuals at increased risk of Alzheimer’s disease.
Researchers at the University of Missouri School of Medicine are investigating the impact of the ketogenic diet on brain metabolism in individuals carrying the APOE4 gene, the most significant known genetic risk factor for late-onset Alzheimer’s. Their recent work, conducted on mice, revealed notable differences based on sex.
The study found that female mice carrying the APOE4 gene exhibited a healthier gut microbiome and increased brain energy levels when fed a ketogenic diet compared too those consuming a high-carbohydrate diet. This positive effect was not observed in male mice, highlighting the potential for sex-specific responses to dietary interventions.
The ketogenic diet alters the brain’s primary energy source. Typically, the brain relies on glucose derived from carbohydrates.However,in individuals with the APOE4 gene – particularly women – this glucose metabolism can become less efficient with age,potentially contributing to cognitive deterioration.
When following a ketogenic diet, the body produces ketones, molecules created from fat breakdown, wich can serve as an choice fuel source for brain cells. Researchers believe this process may protect neurons and reduce the risk of developing Alzheimer’s disease.
the study underscores the importance of personalized nutrition, tailored to individual characteristics. Researchers emphasize that a one-size-fits-all approach is unlikely to be effective, and factors like genotype, gut microbiome composition, gender, and age should be considered.
Experts suggest prioritizing brain health proactively, before the onset of symptoms, as Alzheimer’s disease typically manifests after age 65 and frequently enough involves irreversible damage.
The findings were recently published in the Journal of Neurochemistry.
