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Entertainment

Michal Kocourek: I put the theater on debt and signed everything

by Julia Evans – Entertainment Editor
written by Julia Evans – Entertainment Editor

Kalich Theater Founder Michal Kocourek Reflects on Success, New Talent ⁣Initiative & Tech Disconnect

Prague, czech Republic – ⁢Michal Kocourek, founder of Prague’s Kalich Theater, revealed plans to establish a small conservatory to nurture young ‍talent, despite acknowledging moments of burnout after decades in ⁣the industry. In a recent interview on the Boomer Talk podcast, Kocourek discussed his ​vision for the future of the theater, his⁣ complicated relationship ⁢with modern technology, and a career spanning pre- ‌and post-revolution Czech Republic.

The Kalich Theater currently attracts over 400,000 visitors annually through its theatrical productions, tours, and summer stage performances.Kocourek envisions the ⁢new talent school ‍as a response to a lack of possibility for⁢ promising young performers. He also hopes to create an intimate 70-seat venue, tentatively named Kalíšek, to showcase⁣ emerging artists.”There are a lot of talented young people, ‌but little opportunities,” Kocourek ⁣stated.

Despite his success,‌ Kocourek ⁣admits to feeling out of step with the⁣ digital age. “There are times when I ⁣feel [like a boomer],” he confessed. “I am⁢ most destroyed by technology: applications, computers, I don’t enjoy it and I don’t have a‍ relationship to ​it. I only use it for ‌data or for mails.” He expressed concern ‍over media manipulation and the distortion of information, but noted his perspective is informed by experiencing life before the Velvet Revolution and recognizing ‍the current prosperity.

The ‌ Boomer⁤ Talk podcast, hosted by ⁣Miloš Pokorný and ⁣available on Podcasty.cz, explores comparisons between past and present through interviews with guests from ‍diverse professions. The podcast utilizes ‍the term ​”boomer” satirically,referencing critical older internet users.

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Health

7 Pulmonology Breakthroughs: New Treatments & Guidelines in August 2025

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

7 Pulmonology Headlines You Missed in August 2025: A Month of Firsts & Refined Guidelines

August 2025 marked a significant period for pulmonology, highlighted by the FDAS groundbreaking approval of the first immunotherapy for recurrent respiratory papillomatosis (RRP) and a shift towards disease-modifying treatments for bronchiectasis. Beyond these landmark approvals, updates to sinusitis guidelines and advancements in asthma risk prediction offered further progress in respiratory care. here’s a recap of seven key headlines from the month:

1. First Immunotherapy Approved for Recurrent Respiratory Papillomatosis: The FDA approved zopapogene imadenovec-drba (Papzimeos) as the first immunotherapy for recurrent respiratory papillomatosis in adults. This non-replicating adenoviral vector-based therapy offers a new approach to managing the disease,previously reliant on repeated surgical interventions.

2. Bronchiectasis Treatment Enters a New Era: After a long period without disease-modifying options,the FDA approved brensocatib (Brinsupri) in August,marking a turning point in bronchiectasis care. Pulmonologists are now exploring how to integrate this therapy into a thorough management plan for the chronic and often debilitating condition.

3.Sinusitis Guidelines Prioritize Cautious Antibiotic Use: The AAO-HNSF released its 2025 update to adult sinusitis guidelines,placing a strong emphasis on cautious antibiotic use and shared decision-making with patients. Watchful waiting is now recommended as the preferred initial approach for uncomplicated acute bacterial rhinosinusitis, with amoxicillin (with or without clavulanate) remaining the first-line therapy if antibiotics are necessary.

4. Oral Microbiome Shows Promise in Predicting Childhood Asthma: New research suggests that analyzing a child’s oral microbiome, alongside serum inflammatory markers and asthma attack history, can significantly improve the prediction of future severe asthma attacks. Models incorporating these biomarkers demonstrated high accuracy, surpassing customary measures like FENO and blood eosinophil counts.

5. breaking the Surgery Cycle for RRP: HCPLive spoke with Simon Best, MD, regarding the FDA’s August 14 approval of zopapogene imadenovec-drba (Papzimeos) for RRP. Dr. Best highlighted the therapy’s potential to address a lifelong, HPV 6/11-driven disease that has historically been managed solely through repeated surgeries.

6. Focus on Disease Modification in Bronchiectasis: A special report from HCPLive featuring pulmonologists Albert Rizzo, MD, and James Chalmers, MBChB, PhD, detailed the evolving understanding of bronchiectasis. The report emphasized the disease’s chronic morbidity, frequently enough delayed diagnosis, and the importance of moving towards therapies that modify disease progression, now bolstered by the approval of brensocatib.

7. Positive Trial Results for RRP Immunotherapy: A pivotal Phase 1/2 trial of zopapogene imadenovec-drba (Papzimeos) showed promising results, with 51% of patients achieving complete response and over 85% experiencing reduced surgical interventions. The therapy also demonstrated a favorable safety profile, primarily consisting of mild-to-moderate injection site reactions and systemic symptoms.

These developments signal a period of innovation and refinement in pulmonology, offering new hope for patients and evolving the standard of care across a range of respiratory conditions.

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Entertainment

Jesse Plemons’ Role in ‘Bugonia’ Is the Talk of Telluride

by Julia Evans – Entertainment Editor
written by Julia Evans – Entertainment Editor

Jesse Plemons‘ Performance in Yorgos Lanthimos‘ ‘Bugonia‘ Dominates Telluride Film Festival Conversations

Telluride,Colorado ⁢- ⁤Jesse Plemons is generating ⁤significant buzz ​at the Telluride Film Festival for his demanding role in yorgos Lanthimos’‍ upcoming‍ film,”Bugonia.” The actor ⁢revealed⁣ the uniquely challenging production schedule,driven by simultaneous commitments to “Kinds of Kindness,” limited rehearsal⁣ time,and a relentlessly paced shoot.

Plemons described the “Bugonia” experience as particularly intense, ⁤noting a ⁤lack of opportunity to process scenes due to⁢ the filmS constant forward momentum. “This felt relentless,”‍ Plemons said.”There ​was no opportunity to even process ‍the scene that just happened, that took place today, ​as you have to look at what awful thing is coming.I didn’t know how I was going to do the third act, the ⁤endurance of that. The relentlessness ‌probably helped, because I had to focus on what ​was ⁤at hand.” The film,slated for release ⁢in 2025,is already being ⁣discussed as a potential career high for the​ actor,known for his versatility and nuanced ‍performances.

Beyond “Bugonia,” Plemons is also preparing for a role in the next ​installment of “The Hunger​ Games” ⁣franchise, “Sunrise on⁢ the Reaping,” scheduled for 2026. he will portray Plutarch Heavensbee,a ⁣character previously played by the late Philip Seymour Hoffman. Plemons shared that‌ taking on the ​role gave him pause, recalling his early experience working with Hoffman ‌and Joaquin Phoenix ‌on “The Master.” “It was one of the best classes I’ve ever taken,” he said, “because I have a few scenes with Hoffman and [Joaquin] Phoenix, but I was there ‌for pretty much the duration of the shoot, and so I just watched.”

Plemons’ continued success ⁣across diverse projects solidifies his position as one of the most compelling actors working today, with “Bugonia” poised to be a pivotal moment in ⁣his career. He begins filming “Sunrise on‌ the Reaping” in mid-September.

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Technology

Patients Prioritize Efficacy in Food Allergy Treatment Over Method, Frequency

by Rachel Kim – Technology Editor
written by Rachel Kim – Technology Editor

Patient Preferences ‍for Food Allergy‌ Treatments: Efficacy Tops the List

Table of Contents

Washington, D.C. – August 20,⁣ 2025 – A new study published online today ⁢indicates that individuals in the⁤ United States with food allergies overwhelmingly ‌prioritize treatment effectiveness when⁤ selecting a therapy. Safety⁤ and convenience – including oral management and at-home dosing‍ – also significantly influence ​patient choices,‌ according to research from Broadstreet Health⁢ Economics & ⁣Outcomes Research.

Key Findings ‌of the study

The research, a discrete choice ​experiment involving adolescents and⁢ caregivers, revealed that a 95% reduction⁣ in the risk of moderate-to-severe allergic reactions was the most valued attribute of a ⁤potential treatment. ⁤Participants consistently favored oral medications over injections and preferred administering treatments at home​ rather than in​ a ⁣clinical setting. Less frequent dosing schedules – ⁤every‍ two or four weeks – were also⁤ highly desirable⁢ compared to daily regimens.

“Treatment efficacy was ⁣the most highly ranked treatment feature, followed by risk of gastrointestinal ‍symptoms and method ‌of treatment administration,” ‌explained Alexis T. Mickle, MSc, director at Broadstreet Health Economics & Outcomes Research, and lead investigator of the study. “notably, individuals ‍with prior experience⁣ using oral immunotherapy expressed ‌less concern ‌about dosing ⁢frequency.”

Currently, FDA-approved treatments for food allergies include peanut allergen powder-Dnfp (an oral ⁣immunotherapy), sublingual immunotherapy, omalizumab (a ⁢biologic),​ and epinephrine ‌for anaphylaxis. These options ​vary⁤ in administration,​ potential​ side effects, ⁣frequency,⁤ and required post-treatment precautions.

Study Methodology

The study, conducted between May and June 2024,⁤ included 73 adolescents aged 13 to ‌17 ⁤and 228⁢ caregivers of​ children under⁢ 12‍ diagnosed with ⁣food allergies. The sample population was 55% male,52%‍ White,and predominantly from urban ⁤or suburban areas. Participants evaluated hypothetical treatments with ⁤varying attributes, allowing researchers to assess preferences without directly asking about‌ specific⁤ features.

Researchers collected data on demographics,the ​Intolerance of ‌Uncertainty-12 Scale (IUS-12),and‍ the Food ​Allergy Autonomous Measure (FAIM). ⁢Conditional logistic regression⁣ analyses were used ‌to determine the relationship ⁣between treatment attributes⁤ and patient preferences.

Did You Know? ​Approximately 8% of children in the United ‍States have a food allergy, according⁤ to the Food Allergy ⁣Research & Education (FARE).

Impact of ⁤Prior Treatment Experience

The study highlighted a significant difference in preferences based ⁤on prior treatment experience. Individuals who⁤ had previously used ‍oral immunotherapy ‌(OIT) were less concerned about‌ the frequency of dosing,⁤ potentially because they were already accustomed to the⁤ regimen. This suggests that⁣ managing expectations and providing support during initial treatment phases could ‌be‍ crucial for improving patient⁣ adherence.

Preference for Safety and Reduced Side‍ Effects

Participants demonstrated a strong aversion to treatments with increased​ risks ⁢of gastrointestinal symptoms ⁣or anaphylaxis. A 10% increase in the risk of gastrointestinal issues ⁢resulted in a​ 4% decrease in treatment​ preference,while a 5%⁣ increase‍ in anaphylaxis ⁢risk led to a 6% decrease.This underscores ‍the importance of minimizing potential adverse effects in the advancement of new ⁤food allergy therapies.

Pro ​Tip: ⁣Discuss potential side effects and management‌ strategies with your healthcare⁣ provider before starting any new food allergy treatment.

Caregiver vs. ‍Adolescent Preferences

The study also revealed that‍ caregivers exhibited‌ a stronger⁢ preference for‍ efficacious treatments compared to adolescents. Researchers⁢ speculate this difference might ​potentially⁢ be due to parents⁢ having a ⁣greater ⁢level of concern for their children’s‌ well-being. Additionally, caregivers​ of children with less severe allergies placed a higher​ value on treatment efficacy,⁣ potentially due to less experience managing severe reactions.

Attribute Preferred Option Impact on Preference
Efficacy 95% ‍reduction in allergic reactions OR 1.61 ⁤(95% CI 1.49-1.75)
Administration Oral Significantly preferred over ‍subcutaneous (P < ⁣.001)
Location At-home Preferred‍ over clinical setting (P <.05)
Frequency Every 2-4 weeks Preferred over daily (P < ⁢.001)

What factors are most vital to you when considering a food allergy treatment? How do you weigh the ​benefits against⁤ potential risks?

References

  1. Mickle AT,​ Warren​ CM, Seetasith A, ⁣et al. Patient ​preferences for⁢ food allergy treatments in⁣ the United States: a discrete choice experiment.⁤ Curr Med res‌ Opin. Published⁣ online August ⁤18, 2025. doi:10.1080/03007995.2025.2544596
  2. Food Allergy Treatment & Management. Allergy & Asthma Network. https://allergyasthmanetwork.org/food-allergies/food-allergy-treatment-and-management/. Accessed August 20, 2025.

Food allergies are‌ a growing public health concern, affecting millions of people worldwide. While ⁢there ​is currently ​no⁤ cure, ongoing research is focused on developing more effective and convenient treatments. The⁢ increasing prevalence of food allergies is highly⁤ likely due to a⁢ combination of genetic and environmental factors, including changes​ in diet and exposure to microbes‍ in early childhood. Understanding⁤ patient ⁣preferences is ​crucial for ensuring that new therapies are both effective and acceptable to those ‍who ‌need them.

Frequently Asked Questions About Food Allergy Treatments

  • What is the most important factor patients consider when choosing a food allergy treatment? Treatment efficacy, or how well the treatment reduces‍ allergic ‌reactions, is the most highly ranked attribute.
  • Do patients prefer oral ⁣or ‌injectable food allergy⁤ treatments? Patients overwhelmingly prefer ​oral administration⁣ over subcutaneous ​injections.
  • Is dosing frequency a significant concern for patients? Yes, less frequent dosing schedules (every ⁤2-4 weeks) are⁢ preferred over daily⁣ administration.
  • How does prior‌ experience with oral immunotherapy affect treatment ⁢preferences? Individuals with⁤ prior OIT ‍experience are less ⁣concerned⁢ about dosing frequency.
  • Are caregivers’ preferences⁣ different from those of adolescents? Caregivers ⁤tend to prioritize ⁤treatment efficacy more ‍strongly than adolescents.

This research⁤ provides valuable insights into the factors‍ that drive patient decision-making regarding food allergy​ treatments. By understanding‌ these preferences, healthcare providers and researchers can work ⁣together to develop therapies ‍that are not only effective ⁢but⁢ also ‍meet⁤ the needs and expectations‍ of those living with food allergies.

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Entertainment

Inside Out 2 Writer Meg LeFauve Explains the Pixar Brain Trust

by Julia Evans – Entertainment Editor
written by Julia Evans – Entertainment Editor

Here’s a breakdown of⁣ the text provided, focusing on the Pixar filmmaking process as described by Meg ⁣LeFauve:

Key Stages ‌of⁢ Pixar’s Filmmaking Process (as described):

  1. Idea/Brain Trust (Early Stage):

Starts with⁣ an idea, discussed with a ​small, trusted⁤ “Brain Trust” (fellow ‍directors and storytellers).
 ⁤ This⁤ is ​a very open, exploratory phase. Ideas⁣ are pitched and critiqued.

  1. Outline/Scriptment:

The idea is developed into a more structured outline,sometimes called a “scriptment.”
 ‍ The Brain Trust ‍expands to include ​more⁤ people as ⁤the project becomes more defined.

  1. Script Progress:

⁤ A⁤ full script is written.
 ⁣The Brain Trust continues to provide feedback, which can be very direct (“we like this half,”​ “this could be the best thing ever”).
⁤
Character design begins during this phase.

  1. Storyboarding:

‌ The ‍script is visualized through storyboards.
⁢
LeFauve ⁤notes that a good scene is one that ‍excites the ​storyboard artist to ⁤draw.
 The movie is screened internally in storyboard ⁤form, and feedback is⁤ gathered from the⁤ Brain‍ Trust ⁣again.

Important Insights:

Iteration​ &​ Feedback: The ⁢process is highly iterative. there are multiple rounds‍ of feedback and⁤ revision at‌ each stage.
 Focus on Story: Ideas that don’t serve the core story‍ or ‌character ⁣arcs (like Procrastination Land)‍ are cut, ⁤even if they’re ⁢fun. The focus is always on Riley’s journey and the emotions that​ drive it.
Storyboarding as a Gauge: The ‍enthusiasm of the storyboard artist is a key indicator of⁣ a scene’s strength.
 Brain Trust Importance: The Brain Trust is central to the process, providing ⁢honest and critical ⁢feedback.

Specific Details Mentioned:

Cut ​Ideas: Schadenfreude ⁤(from the first film) and ​Procrastination Land‍ were considered but ultimately cut.
 New Emotion: Anxiety (voiced by⁣ Maya Hawke) is ⁣a central new ⁣emotion in Inside ‌Out ‍2.

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